Protein Info for Sama_2445 in Shewanella amazonensis SB2B

Annotation: multi anti extrusion protein MatE (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 443 transmembrane" amino acids 20 to 41 (22 residues), see Phobius details amino acids 56 to 80 (25 residues), see Phobius details amino acids 97 to 123 (27 residues), see Phobius details amino acids 137 to 157 (21 residues), see Phobius details amino acids 165 to 186 (22 residues), see Phobius details amino acids 192 to 215 (24 residues), see Phobius details amino acids 246 to 266 (21 residues), see Phobius details amino acids 274 to 278 (5 residues), see Phobius details amino acids 283 to 304 (22 residues), see Phobius details amino acids 318 to 336 (19 residues), see Phobius details amino acids 362 to 382 (21 residues), see Phobius details amino acids 391 to 411 (21 residues), see Phobius details amino acids 417 to 436 (20 residues), see Phobius details PF01554: MatE" amino acids 22 to 183 (162 residues), 77.4 bits, see alignment E=5.4e-26 amino acids 244 to 400 (157 residues), 50.6 bits, see alignment E=9.1e-18

Best Hits

KEGG orthology group: None (inferred from 100% identity to saz:Sama_2445)

Predicted SEED Role

"Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A1S8E3 at UniProt or InterPro

Protein Sequence (443 amino acids)

>Sama_2445 multi anti extrusion protein MatE (RefSeq) (Shewanella amazonensis SB2B)
MNHTQAMLEAPVSRLFWRYTLPTIASMLVTGIYVTIDGMFVGHFLGETGLAGIMLAYPVG
ALLYAVGALIGMGAGALVSIKLGEGKTAKARELLGNAFSLVLLSALFFTLVGSVSARHIL
IWLGAEGEVLESAHDYLFWYFALCIFPLISMAFSTLLRNDGKPAFVTWVLIAGGVINTLL
DYLFIVVWDFGLAGASVATMLSQAVTGLLCLQHFFSGKTALRIDFEQMRLKLDNCLNISR
VGLPSLLMNLYLSIVLTLHNTALLWVGTPLHVAAYGVVSYTEAFFYLIFEGIALGSQPVL
SFNAGAGRMDRVRQTRNLAMAVTLLTAGLGLLFIYGRPEWALYIFAGDNPVLSPVAIEGM
RLYFWGLPFEGLILVGASFFQAINKPREASILTGTKLLLIAAVIYSFAWLFGVPGVWVSL
ACVSSVLTLWMVYSLVRIDSQSM