Protein Info for Sama_2017 in Shewanella amazonensis SB2B

Annotation: bicyclomycin resistance protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 401 transmembrane" amino acids 18 to 39 (22 residues), see Phobius details amino acids 57 to 74 (18 residues), see Phobius details amino acids 85 to 103 (19 residues), see Phobius details amino acids 110 to 133 (24 residues), see Phobius details amino acids 144 to 167 (24 residues), see Phobius details amino acids 173 to 192 (20 residues), see Phobius details amino acids 222 to 244 (23 residues), see Phobius details amino acids 256 to 274 (19 residues), see Phobius details amino acids 286 to 307 (22 residues), see Phobius details amino acids 314 to 338 (25 residues), see Phobius details amino acids 348 to 370 (23 residues), see Phobius details amino acids 375 to 395 (21 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 18 to 386 (369 residues), 238.1 bits, see alignment E=1.1e-74 PF07690: MFS_1" amino acids 24 to 364 (341 residues), 139.2 bits, see alignment E=1.7e-44 PF00083: Sugar_tr" amino acids 58 to 181 (124 residues), 23.4 bits, see alignment E=2.7e-09

Best Hits

KEGG orthology group: K07552, MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein (inferred from 100% identity to saz:Sama_2017)

Predicted SEED Role

"Multidrug resistance transporter, Bcr/CflA family" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A1S766 at UniProt or InterPro

Protein Sequence (401 amino acids)

>Sama_2017 bicyclomycin resistance protein (RefSeq) (Shewanella amazonensis SB2B)
MGSPTEAQARTSGLNRAFLIPLLAAIVAITPLAIDMYLPAMSVIALSLGSDVTHVQQSLS
VYLAGYACGLLLFGPMADRYGRRPLVLFGLTGFGICSLLLSHVSTPDAFFGLRFVQAMIG
SAATVVVPGYVKILYGDNTAKGMSYVSLIMMLAPLIAPSIGSFILGFSHWEMIFYVLSGY
ALLALTLVYFGLQIPEVKTEKHQRPGFIEAYRTVLTRAGVKGFIASGVLTSFAFFCYLTA
SPFVFMEVYGLDSQHFAMVFASNVGALMLANILNSRIVGRFGSLRLLRASTLCGLVFALL
LCAANTIELGLYGTLLTLVPLMACLGIMSVNADAIVLLKFQRETGTATAVIGTLRFGIGA
LAGPLLAAFYTGTALPFSALMLFAVLLAGACQHLARRTSIE