Protein Info for Sama_1365 in Shewanella amazonensis SB2B

Annotation: 6-phosphogluconate dehydrogenase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 511 PF03446: NAD_binding_2" amino acids 9 to 182 (174 residues), 114.6 bits, see alignment E=7.3e-37 PF02737: 3HCDH_N" amino acids 10 to 65 (56 residues), 26 bits, see alignment 1.2e-09 TIGR00873: 6-phosphogluconate dehydrogenase (decarboxylating)" amino acids 197 to 502 (306 residues), 432.1 bits, see alignment E=1.3e-133 PF00393: 6PGD" amino acids 211 to 501 (291 residues), 410.8 bits, see alignment E=5.2e-127

Best Hits

KEGG orthology group: K00033, 6-phosphogluconate dehydrogenase [EC: 1.1.1.44] (inferred from 100% identity to saz:Sama_1365)

Predicted SEED Role

"6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)" in subsystem Pentose phosphate pathway (EC 1.1.1.44)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.44

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A1S5B6 at UniProt or InterPro

Protein Sequence (511 amino acids)

>Sama_1365 6-phosphogluconate dehydrogenase (RefSeq) (Shewanella amazonensis SB2B)
MQNHTQLHDIGVIGLGVMGKNLALNIADNGYRVAAFDLDGAKVRAAVSQSQAEVAAKPAH
SKATQLTGVDSLKSMLCALTSPRLLLLSVPAGAPVDGVCSALIDAGIKPDDIVIDTGNSL
WTDTVKREQEYAGKFVFFSSAVSGGEVGARFGPSLMPSGKKEAWDSVAPIWRAIAAKVDN
TTGLPIERFEPGNPVLEGEPCTAYIGPAGSGHYVKMVHNGIEYADMQLICEAYQLLSDVL
GLSAVEIAAIFERWNRGKLNSYLMGISAEVLRQSDPLTGKPLVEMILDKAGQKGTGLWTA
VSSLQIGTPAPTIAEAVYARALSNQKALRTELAGRLAGAMPLQGIDATSFIDELEQALFC
AKICCYAQGFQLMAMNAAEQGWELDFAAIARIWRAGCIIRATFLQSITDAFEAEPKLANL
LIAKSFAEALSEAQQSWRHLVSKAVLAGVPAPCITSALAYYDGYRRETLPANLLQGQRDY
FGAHSFERIDTQAGEKYHLNWSSPARELQKL