Protein Info for Sama_1033 in Shewanella amazonensis SB2B

Annotation: GTP diphosphokinase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 734 PF13328: HD_4" amino acids 45 to 190 (146 residues), 130.8 bits, see alignment E=9.3e-42 TIGR00691: RelA/SpoT family protein" amino acids 64 to 732 (669 residues), 627.6 bits, see alignment E=1.4e-192 PF04607: RelA_SpoT" amino acids 250 to 359 (110 residues), 143.3 bits, see alignment E=9.3e-46 PF02824: TGS" amino acids 403 to 462 (60 residues), 69.4 bits, see alignment 5.2e-23 PF19296: RelA_AH_RIS" amino acids 482 to 637 (156 residues), 48.7 bits, see alignment E=2.5e-16 PF13291: ACT_4" amino acids 657 to 733 (77 residues), 61.7 bits, see alignment E=2.2e-20

Best Hits

Swiss-Prot: 58% identical to RELA_HAEIN: GTP pyrophosphokinase (relA) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K00951, GTP pyrophosphokinase [EC: 2.7.6.5] (inferred from 100% identity to saz:Sama_1033)

Predicted SEED Role

No annotation

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.6.5

Use Curated BLAST to search for 2.7.6.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A1S4D4 at UniProt or InterPro

Protein Sequence (734 amino acids)

>Sama_1033 GTP diphosphokinase (RefSeq) (Shewanella amazonensis SB2B)
MVSVREAHFNDVDFNLEDWVVRYVDDAEDARVLLELLRTVQAMPMKDAKAHDALMSRARE
MIEILAPLNMDLETLQAAVLFSVQEAGLLPQEKLVEKFGDKLGNLVASVVTMNAIGSLKL
SEQSRSAEMQIDNIRKMLLAMVEDVRAVVIKLAERVCLLRAVKNADEETRVLLAREIADI
YAPLANRLGIGQLKWELEDISFRYLHPETYKEIAKQLDGKRIDRETYIEQFVNDLQAKLD
EEHIRAKVYGRPKHIYSIWRKMKGKHLKFDELFDVRAVRIVTDRLQDCYGALGVVHTLYH
HIPREFDDYVANPKPNGYQSIHTIVVGPEGKTVEIQIRTEAMHQDAELGVAAHWKYKEGH
AGKQSGYEEKINWLRKILQWQEDVVESGNLVEEIRSQVFEDRVYVFTPSGEVVDLPAGST
VLDFAYYIHSQVGHKCIGAKVDGRIVPFTYQVETGERIEIITSKHPNPKRDWLNPNLGYI
KTSRARSKIQHWFKQQDRDKNLAAGREMLEVELGRVGLTLKDAASAIERFNMTNMDDLLA
AIGGGDVRLNQVVNHIQSRMRVHEISDEEAVEDLVKKGQHKPIAKTRDQIEVNGVGNLLS
HIAQCCRPVPGDEIFGFITKGRGISVHRADCEQVKELMRAHPERVVDVVWGENYSGGYKI
RLRVLANDRTGLLRDLTSVLAAEKSNVLAMSSSSDIKNQTAAIELELELYNVDGLSRVLS
KLGQVDGVIEARRL