Protein Info for Sama_1016 in Shewanella amazonensis SB2B

Annotation: diaminohydroxyphosphoribosylaminopyrimidine deaminase., 5-amino-6-(5-phosphoribosylamino)uracil reductase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 378 PF00383: dCMP_cyt_deam_1" amino acids 11 to 109 (99 residues), 71.8 bits, see alignment E=5.9e-24 TIGR00326: riboflavin biosynthesis protein RibD" amino acids 15 to 373 (359 residues), 411.1 bits, see alignment E=3.8e-127 PF14437: MafB19-deam" amino acids 32 to 125 (94 residues), 39.5 bits, see alignment E=8e-14 TIGR00227: riboflavin-specific deaminase C-terminal domain" amino acids 154 to 376 (223 residues), 202.6 bits, see alignment E=5.9e-64 PF01872: RibD_C" amino acids 156 to 371 (216 residues), 156.9 bits, see alignment E=8.6e-50

Best Hits

KEGG orthology group: K11752, diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC: 1.1.1.193 3.5.4.26] (inferred from 100% identity to saz:Sama_1016)

Predicted SEED Role

"Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193)" in subsystem Riboflavin, FMN and FAD metabolism (EC 1.1.1.193, EC 3.5.4.26)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.193 or 3.5.4.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A1S4B7 at UniProt or InterPro

Protein Sequence (378 amino acids)

>Sama_1016 diaminohydroxyphosphoribosylaminopyrimidine deaminase., 5-amino-6-(5-phosphoribosylamino)uracil reductase (RefSeq) (Shewanella amazonensis SB2B)
MSNNSVFSALDRAMMARAIMLAKRGQYTTRPNPNVGCVIVNDAGDIVGEGWHIRAGGPHA
EVHALKAAADKARGATAYVTLEPCSHYGRTPPCAKALIDNGLKRVVVAMTDPNPQVAGRG
IKLLQDAGIEVAHGLMEAEARALNPGFLSRMERKRPFVTVKVGASLDGKTALSSGESKWI
TGPEARRDVQRLRAKSCALITGIDTVLLDDPSLNVRHGELGSLGASLTEPELIQPIRVVL
DSQRRMSTDAKLFGITGPILLVSAEPYDEKFLHSLPDFVTCLILPGSHGRIDLAALLSHL
GENCNRVLVEAGGTLAGAFIAAGLCDELVLYQAPKLLGSHGRDMLQLPDYQTMAEVPGLK
LIDERKVGQDWRFTFTVA