Protein Info for Sama_0907 in Shewanella amazonensis SB2B

Annotation: threonine synthase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 62% identical to THRC_HAEIN: Threonine synthase (thrC) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K01733, threonine synthase [EC: 4.2.3.1] (inferred from 100% identity to saz:Sama_0907)

MetaCyc: 60% identical to threonine synthase (Escherichia coli K-12 substr. MG1655)
Threonine synthase. [EC: 4.2.3.1]

Predicted SEED Role

"Threonine synthase (EC 4.2.3.1)" in subsystem Threonine and Homoserine Biosynthesis (EC 4.2.3.1)

MetaCyc Pathways

aspartate superpathway (23/25 steps found)
superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (17/18 steps found)
superpathway of L-isoleucine biosynthesis I (13/13 steps found)
superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
superpathway of L-threonine biosynthesis (6/6 steps found)
L-threonine biosynthesis (2/2 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.3.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A1S408 at UniProt or InterPro

Protein Sequence (428 amino acids)

>Sama_0907 threonine synthase (RefSeq) (Shewanella amazonensis SB2B)
MELYNLKHPDERVSFSQAVKLGLGKDRGLFFPTHIPKLDDVETLLTLPFAQRSKKILGAW
LADELGQNVVDALVDKAFTFEVPLVKVDDTRYCLELFHGPTLAFKDFGARFMAQCLNVLA
GDERLTILTATSGDTGAAVADAFYGLDKVQVCVLYPKGKISLLQEKMFTTLGNNIHTVAV
ESDFDACQALVKQAFDDADVREGLHLNSANSINISRLLAQICYYFEAVAQYRKNFVDAPV
IAVPSGNFGNLTAGFFAKAMGLPVKRFVAATNSNDTVPRYLASANWQVNPTVATMSNAMD
VADPSNWPRVEAIAKVMGWSLAEIDGVALDEQQTRCALLALQEDGYLSEPHAAIAAQALK
ATLGKDERGIFLGTAHPAKFKDVVDHELSLDLPLPPELAAVADKPVLSANLAPDFAALKT
HLFETLRH