Protein Info for Sama_0898 in Shewanella amazonensis SB2B

Annotation: prephenate dehydratase / chorismate mutase / phospho-2-dehydro-3-deoxyheptonate aldolase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01797: chorismate mutase
  • amino acids 7 to 89 (83 residues), 87.9 bits, E=2e-29
• PF01817: CM_2
  • amino acids 11 to 89 (79 residues), 64.9 bits, E=1e-21
• PF00800: PDT
  • amino acids 107 to 287 (181 residues), 194.8 bits, E=1.8e-61
• PF00793: DAHP_synth_1
  • amino acids 487 to 649 (163 residues), 69.4 bits, E=3.6e-23

Best Hits

KEGG orthology group: K14170, chorismate mutase / prephenate dehydratase [EC: 4.2.1.51 5.4.99.5] (inferred from 100% identity to saz:Sama_0898)

Predicted SEED Role

"Chorismate mutase I (EC 5.4.99.5) / Prephenate dehydratase (EC 4.2.1.51) / 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I beta (EC 2.5.1.54)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) or Phenylalanine and Tyrosine Branches from Chorismate (EC 2.5.1.54, EC 4.2.1.51, EC 5.4.99.5)

MetaCyc Pathways

• superpathway of chorismate metabolism (50/59 steps found)
• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• chorismate biosynthesis I (7/7 steps found)
• L-phenylalanine biosynthesis I (3/3 steps found)
• L-tyrosine biosynthesis I (3/3 steps found)
• 3-dehydroquinate biosynthesis I (2/2 steps found)
• L-phenylalanine biosynthesis III (cytosolic, plants) (2/2 steps found)
• L-tyrosine biosynthesis III (2/4 steps found)
• L-phenylalanine biosynthesis II (1/4 steps found)
• L-tyrosine biosynthesis II (1/4 steps found)
• superpathway of L-phenylalanine and L-tyrosine biosynthesis (1/5 steps found)
• bacilysin biosynthesis (1/10 steps found)
• salinosporamide A biosynthesis (3/15 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.5.1.54, 5.4.99.5

Use Curated BLAST to search for 2.5.1.54 or 4.2.1.51 or 5.4.99.5

Sequence Analysis Tools

See A1S3Z9 at UniProt or InterPro

Protein Sequence (659 amino acids)

>Sama_0898 prephenate dehydratase / chorismate mutase / phospho-2-dehydro-3-deoxyheptonate aldolase (RefSeq) (Shewanella amazonensis SB2B)
MEKPQPLSETREQITDIDNTVLQLLARRRELSLEVARSKEVDVRPVRDTQRERELLSRLV
QKGREQGLDPHFVMQLYQSIIEDSVLNQQAYLHGRANPETQKQQYCIAYLGARGSYSYLA
ANRYCQRRQVDMVDLGCQSFDEIVHAVESGHADYGFLPIENTSSGSINEVYDVLQHTSLA
IVGETTIEVGHCLLAKPGTKASDIKTLYAHPQPISQCSRYLARHPGLRLEYCASSAEAME
KVQAADSKDVAAIGSAEGGGLYQLEAIEKGLANQKVNQSRFIVVARKAVAVPEQLPAKCT
LIMATGQKPGALVEALLVLKANNLNMSKLESRPIPGTPWEEMFYLDIDANLASVPMQLAL
KELERITRFIKVLGCYPCETVAPTQLSNAQLLIEPEHFRTDAPEPAAAQARDGDSVPARH
SLGYKETVSEVQAGALLIGNGHSGALAMLSLPDTLEGFEPFLKQLKAAGFAGLVLDNLSE
RPDPAKALDACTKAAEKFGLITAAAVNREDELEHAISRVELILIRGKQMFNQPLLERLGK
LHLPVVLERNTMADIDELLAAADTILAEGNQQLMLCESGVSSFKSSTLATLDLAGLVELK
ARSHLPVLVNPSYAVTPEACPRQAKAVKRLGADGLLLEVSLDTSMADSYLGETLRQFFV