Protein Info for Sama_0729 in Shewanella amazonensis SB2B

Annotation: potassium/proton antiporter (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 572 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details transmembrane" amino acids 22 to 23 (2 residues), see Phobius details amino acids 30 to 46 (17 residues), see Phobius details amino acids 58 to 78 (21 residues), see Phobius details amino acids 88 to 115 (28 residues), see Phobius details amino acids 119 to 141 (23 residues), see Phobius details amino acids 163 to 182 (20 residues), see Phobius details amino acids 191 to 212 (22 residues), see Phobius details amino acids 224 to 255 (32 residues), see Phobius details amino acids 270 to 291 (22 residues), see Phobius details amino acids 300 to 322 (23 residues), see Phobius details amino acids 334 to 357 (24 residues), see Phobius details amino acids 363 to 386 (24 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 19 to 387 (369 residues), 196.9 bits, see alignment E=7.2e-62 PF02080: TrkA_C" amino acids 418 to 483 (66 residues), 48.5 bits, see alignment E=1e-16 PF03471: CorC_HlyC" amino acids 496 to 560 (65 residues), 32.8 bits, see alignment E=8.9e-12

Best Hits

Swiss-Prot: 66% identical to NHAP2_VIBC3: K(+)/H(+) antiporter NhaP2 (nhaP2) from Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

KEGG orthology group: K11105, cell volume regulation protein A (inferred from 100% identity to saz:Sama_0729)

Predicted SEED Role

"K+/H+ antiporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A1S3I1 at UniProt or InterPro

Protein Sequence (572 amino acids)

>Sama_0729 potassium/proton antiporter (RefSeq) (Shewanella amazonensis SB2B)
MIAENMNLLFLVGALLVGLSVVLSPLSSRLGVPILLVFLGVGILAGEDGPGGIQFNDYST
AYLVSNLALAVILLDGGLRTKMSSFRLALWPSLSLATLGVAITTVLTGLLAAWLFDLNLL
MGLLIGAIVGSTDAAAVFSLLKGRALNERVGSTLEIESGSNDPMAVFLTVSLIAMIAAGG
NFDGPGLMRDLALQAGMGLAAGFGGGYLIWHLVNRSVLADGLYPILVLAGGLLLFALSSL
AGGSGILSIYLYGLFLGNRGMRGKHSTLAVMDGLTWLAQIGMFLVLGLLLTPSSLLEVLL
PGLVLALGMIFIARPLAVWISLAPFKRFVARERWFISWVGLRGAVPIILAVFPMMAGLPN
AELYFNLAFCVVLVSLLLQGSTLPLAMKLARVGLPPKPEPISRAGVDIFPASEWEIFVYR
LKPNKWCVGEPLRRLSMPEGTRIAALFREHNLLHPSGSTELAADDVLCVLGQAKDLPALS
QLFSEAPENPAMAGFFGDFMLATSVRLADLAPLYGFGLHEDEVGLTLEDLMHQKLGRNPV
EGDSFEWQGCDWVVRTMEGDCPTCLGLKLKAG