Protein Info for Sama_0580 in Shewanella amazonensis SB2B

Annotation: acetyl-CoA carboxylase multifunctional enzyme accADC, carboxyl transferase subunit alpha/carboxyl transferase subunit beta/biotin carboxylase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01039: Carboxyl_trans
  • amino acids 119 to 212 (94 residues), 41.6 bits, 2.4e-14
• PF00289: Biotin_carb_N
  • amino acids 940 to 1051 (112 residues), 103.5 bits, 3.2e-33
• PF02786: CPSase_L_D2
  • amino acids 1057 to 1264 (208 residues), 203.8 bits, E=8.5e-64
• PF02222: ATP-grasp
  • amino acids 1078 to 1234 (157 residues), 38.9 bits, E=2.5e-13
• PF07478: Dala_Dala_lig_C
  • amino acids 1082 to 1233 (152 residues), 24.3 bits, E=7.1e-09
• PF02785: Biotin_carb_C
  • amino acids 1276 to 1388 (113 residues), 90.4 bits, 2.7e-29

Best Hits

KEGG orthology group: None (inferred from 100% identity to saz:Sama_0580)

Predicted SEED Role

"Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) / Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2) / Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) / Biotin carboxyl carrier protein of acetyl-CoA carboxylase" in subsystem Fatty Acid Biosynthesis FASII (EC 6.3.4.14, EC 6.4.1.2)

MetaCyc Pathways

• biotin-carboxyl carrier protein assembly (3/4 steps found)
• fatty acid biosynthesis initiation (type I) (1/3 steps found)
• propanoyl CoA degradation I (1/3 steps found)
• 2-oxobutanoate degradation I (1/4 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (5/10 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (10/17 steps found)
• jadomycin biosynthesis (3/9 steps found)
• methylaspartate cycle (9/19 steps found)
• 3-hydroxypropanoate cycle (3/13 steps found)
• superpathway of L-methionine salvage and degradation (5/16 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (6/18 steps found)
• glyoxylate assimilation (2/13 steps found)
• superpathway of the 3-hydroxypropanoate cycle (3/18 steps found)
• superpathway of mycolate biosynthesis (21/239 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis
• Propanoate metabolism
• Pyruvate metabolism
• Tetracycline biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 6.3.4.14, 6.4.1.2

Use Curated BLAST to search for 6.3.4.14 or 6.4.1.2

Sequence Analysis Tools

See A1S332 at UniProt or InterPro

Protein Sequence (1517 amino acids)

>Sama_0580 acetyl-CoA carboxylase multifunctional enzyme accADC, carboxyl transferase subunit alpha/carboxyl transferase subunit beta/biotin carboxylase (RefSeq) (Shewanella amazonensis SB2B)
MTTNKQPKNMTQAQKPDPLFLQAEHLAKDFSLFPEHSKQSLSEEIKGLLDDAAIQTNLKS
LAKLDVDGYVAKVIQPTQDKNRPGAKRIIADLKGKVITETHMGSFYSAEVDLNFGSRTRR
IGFVAQERTTANGAWMPEHHLAACKAIRHFAELSMPIVYLIDTPGADAGEIANSNNQAHS
ISKAIAESANVDVPTVGIVIGAGYSGGAIPLAAANILLSLRDGIFNTIQPQGLQSIARKY
NLSWQECAKSVGVSPEELYNAGCIDGIIDFSPSDRDERQHNLRRAIISSIEAVERAAVNF
VKESKDLREHYERSLTRFLNPSNSLKALESTADMAVASSPTMHLNLFGSAYRYLRYLTLR
SRIHSISMEQYGRLSKVSVPEGDLLERIQKEQEKVFQAWLSAPDKVVYDEELSKLWNNFV
NKRSEVSTERNMLTRLILGEPKENYKKAKKALLFNIGWSLYHRWKSNAANNFKGLIHYLE
TLPAEVTEANWPELNNLTVLDVVVNKELREDFIWQCYNILIFNALYDNVVGSLASIAKEA
MMSKSLSRASVDSLLHKAIDRALSTQDIANDKSKFYKWLKYFMSQSNRAELLTKTEQWKS
VGFPQLNDSLFVILTYFFERLLPEYFDSEDDTGKYTGAINPVRIGRRKDFWNRLTMGYQD
LLIQKVLRDEKKAGKMTWENVINKFFTNFDELNGDKMTANLLNFPGFRLSIEDALDKGIR
PCGLITGMADFEHKGASLKVGIAVSNTAFQAGAFDMASAEKFSALLIECAKRHMPVICFI
SSGGMQTKEGAAALFSMAVVNDRITRFIRDNELPVLMFGFGDCTGGAQASFVTHPLVQTY
YLSGTNMPFAGQMVVPAYLPSTSTLSNYLSKVPGAMNGLVYNPFSDTLDSQLSSIDPLMP
MPTQKIEEVIKGAISTLVPEAQVVDEEIRQDDPRALMKPIDKVLVHARGCTAVKLIRKAH
DNNINVVLVASDPDMTAVPADMLKENDKLVCLGGNTSDESYLNAYSVLKVAEYENVDALH
PGIGFLSESPQFAALCVNNGVNFVGPSVHSMTTMGNKSNAIKTSQAQNVPVVPGSHGILS
NAEQAVNVASEIGYPVLLKAVQGGGGKGIQVVKRPEDMIPLFMKTSTEAAAAFGNGDLYL
EKYVTSLRHIEVQLLRDKFGNAKVLGLRDCSVQRNNQKVIEESGSTMLPPELKQQVMAYT
KSLGDAVDYMGAGTVEFIYNLDANEVYFMEMNTRLQVEHPVTEATSGIDIVSAQFDIAAG
RSIEDLEPQEIGYAMEVRVTAEKAALDSNGVLQLVPNPGKITECVMPERDDVEIISIAAE
GKEVSPYYDSLIAQIIIRGESREDVVTKMYDYLDSVVIKGIATNIPLLKRILKDATFNEG
VYDTNYLPRLMAELDIPELIAEMEAAAETQGVDTESLRVGDSNELKVLAQGAGIFYSSPA
PGEPEFVREGDIVTTDTTLALTEAMKMFSQVTLASFNRKGAVLYPEDKKYRIERILNTNG
QQVSQGDLLFVVSPVED