Protein Info for Sama_0562 in Shewanella amazonensis SB2B

Updated annotation (from data): D-mannose transporter (MFS superfamily)
Rationale: Specific phenotype on mannose and no other transporter is apparent in the fitness data.
Original annotation: glucose/galactose transporter (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 413 transmembrane" amino acids 23 to 42 (20 residues), see Phobius details amino acids 61 to 83 (23 residues), see Phobius details amino acids 90 to 108 (19 residues), see Phobius details amino acids 114 to 138 (25 residues), see Phobius details amino acids 158 to 179 (22 residues), see Phobius details amino acids 187 to 210 (24 residues), see Phobius details amino acids 231 to 253 (23 residues), see Phobius details amino acids 273 to 290 (18 residues), see Phobius details amino acids 297 to 316 (20 residues), see Phobius details amino acids 322 to 345 (24 residues), see Phobius details amino acids 357 to 376 (20 residues), see Phobius details amino acids 382 to 402 (21 residues), see Phobius details PF07690: MFS_1" amino acids 31 to 358 (328 residues), 79.1 bits, see alignment E=1.6e-26 TIGR01272: glucose/galactose transporter WARNING" amino acids 105 to 399 (295 residues), 321.8 bits, see alignment E=2.7e-100

Best Hits

KEGG orthology group: None (inferred from 100% identity to saz:Sama_0562)

Predicted SEED Role

"Predicted mannose transporter, GGP family" in subsystem Mannose Metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A1S314 at UniProt or InterPro

Protein Sequence (413 amino acids)

>Sama_0562 D-mannose transporter (MFS superfamily) (Shewanella amazonensis SB2B)
MAFVSSTTPQNGSAAPAQSHQQLLFGAMTSLFFIWGFITALNDILIPHLKGIFDLSYTQA
MLVQFCFFGAYFLVSPLAGVLIARIGYLRGIIFGLSTMATGCLLFYPASSLEQYALFLLA
LFVLASGITILQVSANPFVARLGPERTAASRLNLAQALNSLGHTLGPLFGSLLIFGAAAG
THEAVQLPYLLLAAVIGIIAVGFIFLGGKVKHADMGVDHRHKGSLLSHKRLLLGALAIFL
YVGAEVSIGSFLVNYFAEPSIGGLDEKSAAELVSWYWGGAMIGRFAGAALTRRFNPAMVL
AANAVFANLLLMLTIVSSGELALVAVLAVGFFNSIMFPTIFTLAIEGLGELTSRGSGLLC
QAIVGGALLPVIQGVVADNVGVQLSFIVPTFCYFYICWYAFFARNRMNGETAS