Protein Info for Sama_0538 in Shewanella amazonensis SB2B

Name: dipZ
Annotation: thiol:disulfide interchange protein precursor (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 607 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 194 to 220 (27 residues), see Phobius details amino acids 238 to 261 (24 residues), see Phobius details amino acids 273 to 293 (21 residues), see Phobius details amino acids 315 to 339 (25 residues), see Phobius details amino acids 352 to 373 (22 residues), see Phobius details amino acids 390 to 411 (22 residues), see Phobius details amino acids 417 to 433 (17 residues), see Phobius details amino acids 446 to 471 (26 residues), see Phobius details PF11412: DsbD_N" amino acids 36 to 145 (110 residues), 93.5 bits, see alignment E=2.8e-30 PF02683: DsbD_TM" amino acids 195 to 410 (216 residues), 309.4 bits, see alignment E=3.3e-96 PF13386: DsbD_2" amino acids 221 to 403 (183 residues), 27.3 bits, see alignment E=9.8e-10 PF13899: Thioredoxin_7" amino acids 496 to 578 (83 residues), 50 bits, see alignment E=8.2e-17 PF00085: Thioredoxin" amino acids 508 to 579 (72 residues), 25.5 bits, see alignment E=3.2e-09 PF13098: Thioredoxin_2" amino acids 508 to 601 (94 residues), 38 bits, see alignment E=5.5e-13

Best Hits

KEGG orthology group: K04084, thiol:disulfide interchange protein DsbD [EC: 1.8.1.8] (inferred from 100% identity to saz:Sama_0538)

Predicted SEED Role

"Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8)" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange (EC 1.8.1.8)

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.8

Use Curated BLAST to search for 1.8.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A1S2Z2 at UniProt or InterPro

Protein Sequence (607 amino acids)

>Sama_0538 thiol:disulfide interchange protein precursor (RefSeq) (Shewanella amazonensis SB2B)
MKKIITLLFSCLLLLAPSTHANDIFGKKFDFLKGEPELMPVNEAFVFDAVQDGNRVRVSF
VIADGYYLYRDKLKFEADNATLGEVALPPGKLHNDEYFGEQQVFYSYVEFTVALKEAMDQ
GTLTLTFMGCAEGKLCFPPTRVSKQLTAVAPNDGKLSGESAKPVSDGTVSGTSTSAPLTQ
QDSLAQMLTEGNLGWTLLIFFGLGIGLALTPCVFPMYPILSGIIVGQGEKLSTGRAFTLS
MAYVQGMAITYSLLGLVVASAGMKYQAALQHPAVLIGLAILFFVLSLSMFGLYDLKLPSS
WQEKMNGLSNNQKGGNLTGVFIMGVISGLVASPCTTAPLSGALVYVAQSGDLLMGFAALY
VLSMGMGLPLLLMGTSGGKLLPRAGAWMEIIKTVFGFLLIAVSVMMIGRIWPGMVSDLLW
ALWGVALAGYLLHQNKKTEFNWKQTVRTVLLMLGLLAAFSYGFQAVMGGLGYQMPTNNTA
QQSVKGVEFKRIKSVEDLNAELAIARFEGKFVMLDLYADWCVACKEFEHITFPDPEVKKR
LDNMVLLQADVTKSDAIDVTLLETYDVLGLPTLLLFDPQSGLRDDLRVTGFMGPKDFAAH
LDLLQVH