Protein Info for Sama_0381 in Shewanella amazonensis SB2B

Annotation: 2-deoxyglucose-6-phosphatase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 221 PF00702: Hydrolase" amino acids 6 to 182 (177 residues), 107.2 bits, see alignment E=2.2e-34 PF13419: HAD_2" amino acids 9 to 189 (181 residues), 105.6 bits, see alignment E=5.3e-34 TIGR01509: HAD hydrolase, family IA, variant 3" amino acids 90 to 187 (98 residues), 45.4 bits, see alignment E=9.9e-16 TIGR01549: HAD hydrolase, family IA, variant 1" amino acids 104 to 182 (79 residues), 25.5 bits, see alignment E=1.5e-09 PF13242: Hydrolase_like" amino acids 144 to 190 (47 residues), 24.2 bits, see alignment 3.8e-09

Best Hits

Swiss-Prot: 44% identical to HXPB_ECO57: Hexitol phosphatase B (hxpB) from Escherichia coli O157:H7

KEGG orthology group: None (inferred from 100% identity to saz:Sama_0381)

MetaCyc: 44% identical to hexitol phosphatase B (Escherichia coli K-12 substr. MG1655)
2-deoxyglucose-6-phosphatase. [EC: 3.1.3.68]; Sorbitol-6-phosphatase. [EC: 3.1.3.68, 3.1.3.50]; Mannitol-1-phosphatase. [EC: 3.1.3.68, 3.1.3.50, 3.1.3.22]

Predicted SEED Role

"2-deoxyglucose-6-phosphate hydrolase YniC" in subsystem 2-phosphoglycolate salvage

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.3.22 or 3.1.3.50 or 3.1.3.68

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A1S2I6 at UniProt or InterPro

Protein Sequence (221 amino acids)

>Sama_0381 2-deoxyglucose-6-phosphatase (RefSeq) (Shewanella amazonensis SB2B)
MLTNRIDAVIFDMDGILIDSEPVWQLAEYEVLAGLGLPIKPEDIHDTVGLRIDMVVDYWY
RRYPWDNYDNAAVAKQIVDGVVAHILSEGVPMKGVIEALDYCRQKGLKIGLATSSSWAII
DAVLDTLNIRDYFDAMESAEHLAFGKPHPEVYLKCADALGVPARHCLAVEDSFNGLIAAR
AATMQTLAIPPAHEREQTRWAVAHVKAEDLTALPKLLANQG