Protein Info for Sama_0063 in Shewanella amazonensis SB2B

Name: gpsA
Annotation: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02558: ApbA
  • amino acids 7 to 114 (108 residues), 29.6 bits, E=1.2e-10
• PF01210: NAD_Gly3P_dh_N
  • amino acids 7 to 160 (154 residues), 169.3 bits, E=1.6e-53
• PF07479: NAD_Gly3P_dh_C
  • amino acids 183 to 323 (141 residues), 186.8 bits, E=5.9e-59
• PF20618: GPD_NAD_C_bact
  • amino acids 243 to 309 (67 residues), 86.9 bits, E=2.8e-28

Best Hits

Swiss-Prot: 100% identical to GPDA_SHEAM: Glycerol-3-phosphate dehydrogenase [NAD(P)+] (gpsA) from Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)

KEGG orthology group: K00057, glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC: 1.1.1.94] (inferred from 100% identity to saz:Sama_0063)

MetaCyc: 76% identical to glycerol-3-phosphate dehydrogenase (Escherichia coli K-12 substr. MG1655)
Glycerol-3-phosphate dehydrogenase (NAD(P)(+)). [EC: 1.1.1.94]

Predicted SEED Role

"Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94)" in subsystem Glycerol and Glycerol-3-phosphate Uptake and Utilization or Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 1.1.1.94)

MetaCyc Pathways

• phosphatidylglycerol biosynthesis I (6/6 steps found)
• phosphatidylglycerol biosynthesis II (6/6 steps found)
• superpathway of phospholipid biosynthesis III (E. coli) (10/12 steps found)
• CDP-diacylglycerol biosynthesis I (4/4 steps found)
• CDP-diacylglycerol biosynthesis II (4/4 steps found)
• superpathway of cardiolipin biosynthesis (bacteria) (10/13 steps found)
• glycerol-3-phosphate shuttle (2/2 steps found)
• CDP-diacylglycerol biosynthesis III (4/5 steps found)
• glucosylglycerol biosynthesis (3/5 steps found)
• phosphatidate biosynthesis (yeast) (3/5 steps found)
• 1,3-propanediol biosynthesis (engineered) (4/9 steps found)
• superpathway of phospholipid biosynthesis II (plants) (10/28 steps found)

KEGG Metabolic Maps

• Glycerophospholipid metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.94

Sequence Analysis Tools

See A1S1L9 at UniProt or InterPro

Protein Sequence (339 amino acids)

>Sama_0063 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase (RefSeq) (Shewanella amazonensis SB2B)
MKDTADITVLGAGSYGTALAISLASNGHKTLLWGHDPEHIATLSRERCNAAFLPGISFPD
CLVMEADLGKALAASRNVLVVVPSHVFGDVLRQAKSLLRADARIVWATKGLEPETGRLLQ
DVARDALGDAFPLAVLSGPTFAKELAAGLPTAISVAGTDAGFTADLVELLHSPKRLRVYA
NDDFIGLQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLVELSRLGEALGAQQATFM
GMAGLGDLVLTCTDNQSRNRRFGLALGKGCDVNTAQSEIGQVVEGYRNTKEVFTLAKRLG
VEMPITEQIYAVLYQGKSPLDAAKELLAREKKSETAAAD