Protein Info for Shew_3766 in Shewanella loihica PV-4

Annotation: CzcA family heavy metal efflux protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1017 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details transmembrane" amino acids 334 to 353 (20 residues), see Phobius details amino acids 359 to 379 (21 residues), see Phobius details amino acids 389 to 411 (23 residues), see Phobius details amino acids 433 to 453 (21 residues), see Phobius details amino acids 465 to 492 (28 residues), see Phobius details amino acids 523 to 542 (20 residues), see Phobius details amino acids 858 to 877 (20 residues), see Phobius details amino acids 884 to 904 (21 residues), see Phobius details amino acids 911 to 934 (24 residues), see Phobius details amino acids 956 to 975 (20 residues), see Phobius details amino acids 987 to 1013 (27 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1017 (1017 residues), 943.8 bits, see alignment E=6e-288 PF00873: ACR_tran" amino acids 6 to 1013 (1008 residues), 926.3 bits, see alignment E=1.1e-282

Best Hits

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 100% identity to slo:Shew_3766)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QJI4 at UniProt or InterPro

Protein Sequence (1017 amino acids)

>Shew_3766 CzcA family heavy metal efflux protein (RefSeq) (Shewanella loihica PV-4)
MLTSVIRFSLTQRLFVLIVAAILMAAGGKAWLAIPLDAFPDISPTQVKIILKAPGMTPEE
IEAQITVPIETELLGIPNQAILRSTTKYAISDITLDFAEGTDIYWARQQVSERLAAVWDS
FPEGVSGGVAPMSTPLSEIFMFSLENPNLSLMERRQLLEWEVRPLLRTVPGVADVNILGG
YAKSFSISPNPAAMAAAGIGFADLQQAIKDNNHNEGAGKLTIGTDTIIVRAEGRIDDIDE
LGQLVVKADDAKVYRLKDLAEIQIGHLARYGAVTKDGDETAEALIIALKDTNTAQVVDGI
KQKLAQIQTSLPEGSVINTFYDRANLINTAIDTISSALFEAVLLVIVLLALFLGNVRAAL
VVSLSLPLAALMTFLLMDLFDLSANLMSLGGLVIAIGMLVDSSVVVVENMVNQIASKQRL
PRLHLIFRATKDVAIPVVSGTIIVIIVFSPLLSLTGLEGKLFTPVAVTIVFAMLSSLVLA
LTVIPVIASYLVNEKAAQEPRAIEKLKAAYLGSLKRTFEAKKGFMLTAFSLLIVSLGLFS
LVGKTFMPTLDEGDIILQLEKSPSISLEASIAIDKQIQQTLLSKVPEIKQMVARTGADEI
GLDPMGLNETDVFLELAPRSEWRFDTKAELIEAIRGELLQYAGVNFNFTQPIQMRVSEML
TGSIGDVAIKVFGTDIDTLGTLTGEIQQLVSATNGSVDVKMSLIEGSPFINLTLDNELAR
GFGMSTMEFARYLKSQLEGVAVTEVLQGKKRTPVLIASGEGKLGSINELKQQLLVMPDHS
LRRLTDVAKLSYKEGPILIEREQGDRFSVITTNVEGRDIVGFVEELNAKIGEQIKLPAGY
SVSFGGEFENQQRATNNLLLVIPIAMALITLILFTTFGSLSKAGLILANVPFAMMGGIVS
LYLSGEYLSVPASVGFIALLGVAVLNGVVMVSYYEQTRHLFSDLLTRVEQGAMRRLRPIL
MTATTAMFGLMPLVFATGPGAEIQKPLAIVVIGGLLTSTITTLYLLPILYYWLEKRR