Protein Info for Shew_3426 in Shewanella loihica PV-4

Annotation: endothelin-converting protein 1 (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 684 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF05649: Peptidase_M13_N" amino acids 51 to 428 (378 residues), 396.2 bits, see alignment E=2.1e-122 PF01431: Peptidase_M13" amino acids 480 to 681 (202 residues), 250.4 bits, see alignment E=1.3e-78

Best Hits

KEGG orthology group: K01415, endothelin-converting enzyme [EC: 3.4.24.71] (inferred from 100% identity to slo:Shew_3426)

Predicted SEED Role

"Peptidase, M13 family"

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.71

Use Curated BLAST to search for 3.4.24.71

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QIJ4 at UniProt or InterPro

Protein Sequence (684 amino acids)

>Shew_3426 endothelin-converting protein 1 (RefSeq) (Shewanella loihica PV-4)
MKKVSHLALAVALGLGLGACGSHDTTQVESVQATKVSGVEKENFDTQVRHQDDFYYSVNG
HWLANTPIPADKSNYGAFSVLYEQSQNALKEIIDEVAAMPNKAEGSNEQKVGDFYASYMN
TDLVEQLGVTPIKAPMAEIAGLKSHQDVANQMGKLLVSGVQMPLGFYVNNDAKKSTQYGV
YFYQSGLTLPDRDYYLKDDAKFVANRAALQSYVTDLLAAAGYANAERAANNVAEIERFLA
ESQWTRTESRDANKSYNKMDIAGLQKTVSNFDYSQFANGADMNKVTEVIVRQPSFFEKFG
KQFNQFSVEQWQDYLMFHLVDSSAELLNKQMVDLHFAFHSKTLMGIEEQKPRWKKAVDAA
DQVIGELVGQEYVKRHFKPEAKARMEKMIHNLIKGFEVSINELEWMTPETKVAAQEKLSK
FNYKIGYPDKWKDYTDLSIKADDLVGNYLRYAHFEYKTMLDKLGKPIDRTEWHMTPQTVN
AYYSPVMNEIVFPAAILQPPFFNMDADDAINYGGIGAVIGHEISHGFDDQGAKYDGDGNL
RDWWSDKDREEFKKRGAQLSAQYSGYEALPGKFVNGDLTLGENIGDLGGLTVAARSYQLS
LNGKEAPVIDGLTGEQRLFIGWSQVWRRNYRDEELGRRLLTDPHSPSHFRAMGTPRNIPA
FYEAFDVKAGDKMYLSEEDRVKIW