Protein Info for Shew_3425 in Shewanella loihica PV-4

Annotation: 2-deoxyglucose-6-phosphatase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 223 PF00702: Hydrolase" amino acids 7 to 183 (177 residues), 118.1 bits, see alignment E=1.3e-37 TIGR01509: HAD hydrolase, family IA, variant 3" amino acids 8 to 189 (182 residues), 69.7 bits, see alignment E=3.2e-23 PF13419: HAD_2" amino acids 9 to 188 (180 residues), 114.1 bits, see alignment E=1.7e-36 TIGR01549: HAD hydrolase, family IA, variant 1" amino acids 105 to 182 (78 residues), 23.4 bits, see alignment E=6.8e-09 PF13242: Hydrolase_like" amino acids 144 to 189 (46 residues), 28.9 bits, see alignment 1.7e-10

Best Hits

Swiss-Prot: 45% identical to HXPB_ECO57: Hexitol phosphatase B (hxpB) from Escherichia coli O157:H7

KEGG orthology group: None (inferred from 100% identity to slo:Shew_3425)

MetaCyc: 45% identical to hexitol phosphatase B (Escherichia coli K-12 substr. MG1655)
2-deoxyglucose-6-phosphatase. [EC: 3.1.3.68]; Sorbitol-6-phosphatase. [EC: 3.1.3.68, 3.1.3.50]; Mannitol-1-phosphatase. [EC: 3.1.3.68, 3.1.3.50, 3.1.3.22]

Predicted SEED Role

"2-deoxyglucose-6-phosphate hydrolase YniC" in subsystem 2-phosphoglycolate salvage

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.3.22 or 3.1.3.50 or 3.1.3.68

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QIJ3 at UniProt or InterPro

Protein Sequence (223 amino acids)

>Shew_3425 2-deoxyglucose-6-phosphatase (RefSeq) (Shewanella loihica PV-4)
MSQINLAAVIFDMDGVLIDSEPSWQAAEYKVLSQLGLPISLSDTEQTTGLRIDQVVEYWY
RRHPWKGYDNAATAEAIVTQVAGEILSHGEVMSGVKEALEACKQRGLKLGLATSSPTLLI
DAVMQKLAIRELFDAIVSAEALALGKPHPEVYLNCAKALGVTPSQCLAVEDSFNGLIAAR
AANMHTVVIPAPHEASQARWAAAHQQLTSLKEFADYLAQCAAK