Protein Info for Shew_3378 in Shewanella loihica PV-4

Annotation: Sec-independent protein translocase, TatC subunit (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 251 transmembrane" amino acids 20 to 37 (18 residues), see Phobius details amino acids 70 to 93 (24 residues), see Phobius details amino acids 108 to 135 (28 residues), see Phobius details amino acids 156 to 181 (26 residues), see Phobius details amino acids 193 to 210 (18 residues), see Phobius details amino acids 216 to 234 (19 residues), see Phobius details TIGR00945: twin arginine-targeting protein translocase TatC" amino acids 7 to 224 (218 residues), 246 bits, see alignment E=2e-77 PF00902: TatC" amino acids 9 to 219 (211 residues), 235.3 bits, see alignment E=3.2e-74

Best Hits

Swiss-Prot: 64% identical to TATC_HAEIN: Sec-independent protein translocase protein TatC (tatC) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K03118, sec-independent protein translocase protein TatC (inferred from 100% identity to slo:Shew_3378)

MetaCyc: 60% identical to twin arginine protein translocation system - TatC protein (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-181

Predicted SEED Role

"Twin-arginine translocation protein TatC" in subsystem Cluster-based Subsystem Grouping Hypotheticals - perhaps Proteosome Related or Twin-arginine translocation system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QIE6 at UniProt or InterPro

Protein Sequence (251 amino acids)

>Shew_3378 Sec-independent protein translocase, TatC subunit (RefSeq) (Shewanella loihica PV-4)
MSQQQPLISHLLELRNKLLKAIGSVLLVFICLVYWANDIYHYMATPLMQALPESSSMIAT
DVAAPFFAPFKLTLILAFFIAIPYVLYQIWSFIAPGLYKHEKRLMVPLLASSTILFYLGI
AFTYYIVFPVVFGFFTSVAPEGVQVATDISSYLSFVLKLFFAFGLAFEIPIAVILLCWAG
VTTVEDLRAKRPYIIVGAFVVGMLLTPPDIISQTMLAVPMLILFEGGLIAARFYSKKDSD
EDELSEQDNAE