Protein Info for Shew_3266 in Shewanella loihica PV-4

Name: dipZ
Annotation: thiol:disulfide interchange protein precursor (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 602 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 192 to 218 (27 residues), see Phobius details amino acids 238 to 260 (23 residues), see Phobius details amino acids 272 to 293 (22 residues), see Phobius details amino acids 314 to 339 (26 residues), see Phobius details amino acids 352 to 373 (22 residues), see Phobius details amino acids 389 to 411 (23 residues), see Phobius details amino acids 416 to 432 (17 residues), see Phobius details amino acids 444 to 465 (22 residues), see Phobius details PF11412: DsbD_N" amino acids 37 to 147 (111 residues), 108.2 bits, see alignment E=8e-35 PF02683: DsbD_TM" amino acids 193 to 409 (217 residues), 310.8 bits, see alignment E=1.3e-96 PF13386: DsbD_2" amino acids 220 to 402 (183 residues), 32.8 bits, see alignment E=2e-11 PF13899: Thioredoxin_7" amino acids 491 to 573 (83 residues), 58.8 bits, see alignment E=1.5e-19 PF00085: Thioredoxin" amino acids 499 to 576 (78 residues), 30.6 bits, see alignment E=8.7e-11 PF13098: Thioredoxin_2" amino acids 501 to 596 (96 residues), 46.9 bits, see alignment E=9.1e-16

Best Hits

KEGG orthology group: K04084, thiol:disulfide interchange protein DsbD [EC: 1.8.1.8] (inferred from 100% identity to slo:Shew_3266)

Predicted SEED Role

"Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8)" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange (EC 1.8.1.8)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QI34 at UniProt or InterPro

Protein Sequence (602 amino acids)

>Shew_3266 thiol:disulfide interchange protein precursor (RefSeq) (Shewanella loihica PV-4)
MKKILFLFLSTLLLIAPGAQSESLFSNSKFDFLKDEPQLMPVDQAFVFDAQQEGNLVKIS
WVIADGYYLYRDKLKFTADGATLGEIQLPKGKAHSDEYFGEQQVYYSYVEVPVALKEATA
EANISVTFMGCAEGKLCFPPTTRSAPLTQVAANAGLLPEAMKATPVASETASNQAPITQQ
DSLSQMLSGDNLLWTLVIFFGLGIGLALTPCVFPMYPILSGIIVGQGEKLSTGKAFSLSM
VYVQGMAITYSLLGLIVASAGMKYQAALQHPAVLVGLAILFLVLSLSMFGLYELRLPSSW
QEKMNRFSNNQKGGNVLGVFVMGIISGLVASPCTTAPLSGALVYVAQTGDLMQGFLALYV
LSMGMGLPLLIIGSSGGKLLPRAGAWMDVIKTVFGFLLIAVSILMIGRIWTGLVSDLLWA
LWGVSLTAYLMHQNKLTEFNWKQTVRSVLLLLALLGSFSYGFQAVMTSLGYQAHTGAVSH
KVSHKTIKSLEDLQAEVAAASAQGKPVMLDLYADWCVACKEFEKITFVDPEVQARLSQMV
FLQADVTKNDAIDIELLEHYEVLGLPTLLMFDAKGEIRDELRVTGFMKPAEFAAHLDHLL
AK