Protein Info for Shew_3193 in Shewanella loihica PV-4

Annotation: endonuclease/exonuclease/phosphatase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 871 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details transmembrane" amino acids 851 to 867 (17 residues), see Phobius details PF00932: LTD" amino acids 20 to 128 (109 residues), 59.8 bits, see alignment E=3.3e-20 PF03372: Exo_endo_phos" amino acids 470 to 825 (356 residues), 27.8 bits, see alignment E=2.1e-10 TIGR03501: GlyGly-CTERM domain" amino acids 851 to 871 (21 residues), 20.8 bits, see alignment (E = 2.4e-08)

Best Hits

KEGG orthology group: K07004, (no description) (inferred from 100% identity to slo:Shew_3193)

Predicted SEED Role

"Extracellular and/or outer membrane deoxyribonuclease NucH/SO1066"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QHW1 at UniProt or InterPro

Protein Sequence (871 amino acids)

>Shew_3193 endonuclease/exonuclease/phosphatase (RefSeq) (Shewanella loihica PV-4)
MDNVKKLSVLALSIAAALPVSAKADLLISEYVEGNSNNKAIELYNSGDAALDLTGYKLVR
YKDGDTNALDMVALDGLTIDAKKLKVILHPSAEIALDSDVDSSTGNLYFNGGDAVALVKD
GAVVDIIGAVPTPSGWGMNVTMQRNTDALVASNVFVESQWKVLPVDTFTGLGNLDGASAP
TEPEAPAFTCTGAKITPIYSVQGAGKSSPLIADGEYASKEEVTIRGVVTARGDSLFKGFY
LQEVEGDNSPYTSDGIFVFLGEAAGEEIQPGVEVCVQGLVKEYYGLTQVDIKADKKIEVG
ENVGAPAAQPFYVADGESLGDALERFEGMHVVLDAGSDMKVSRTFSYDYAARRNNMMLSH
KAPLMKATQLYPAMSDEAIALEAQNRANQLFIESDYKAKDGEVPYFPTFNAENGYIRVGD
QLTNLQGVVSYSYNEYRLVATNEIVAGDFIRGDDRSDAPAIATKGDIRVASFNVLNFFNN
AVGGDDTPADNRGANTEEEMLLQRTKIVNAITAMNADIVGLMEIGNNGFGEKSAIQNLLD
ALNAELSDADAYSFVEINDADKYQGKFVGSDAITVGMLYRAAKVTPSGDAFLIATPEQHA
TAGVVTRGEGDKAELSPAFDKYQRHSLGQTFKIHDEQLTVVVNHLKSKGSGCVEDWANYE
DNSDPADLQGKCNEFRVSAAKVIGDALQDVKGDLLVIGDMNAYGKEDPIRVLTDFDAANS
DRDIMTASWTTLDGKVYEREGSKIEKGYGLINLNTKVHGPDTYSYSYNGELGNLDHALAN
TSLAERVLDIQDWHINAVESNLFEYGSKYTGELAKSENAFSASDHDPVIVALSYPVPKPE
PKPEPEEKDDGGSLGYLGLMLLGLAGLRRRN