Protein Info for Shew_3023 in Shewanella loihica PV-4

Annotation: diguanylate cyclase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 362 transmembrane" amino acids 24 to 46 (23 residues), see Phobius details amino acids 52 to 71 (20 residues), see Phobius details amino acids 78 to 97 (20 residues), see Phobius details amino acids 102 to 119 (18 residues), see Phobius details amino acids 126 to 143 (18 residues), see Phobius details amino acids 149 to 173 (25 residues), see Phobius details PF20966: MASE6" amino acids 21 to 184 (164 residues), 47.6 bits, see alignment E=2e-16 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 192 to 350 (159 residues), 156.9 bits, see alignment E=1.9e-50 PF00990: GGDEF" amino acids 195 to 347 (153 residues), 152.4 bits, see alignment E=9.7e-49

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_3023)

Predicted SEED Role

"GGDEF domain protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QHE1 at UniProt or InterPro

Protein Sequence (362 amino acids)

>Shew_3023 diguanylate cyclase (RefSeq) (Shewanella loihica PV-4)
MLKYWYKDFAQYPPGHRDYWRTRLIGHTLLLSSSFFLVLTLLNIFYFESYEYATLDASGF
VLSLSILAFFNRTANVNLASWAVTLMVTGLILLFVASVGGYAHSLYWATLIPPFAFFLLG
RQRGSLVSLIAFGVCAYIVYNQIQEARPVTFGMGALFNVIEVSIAHILLFRFYEGTRSSA
YRQLGERNAKIQKLAETDKLTGLYNREKLDITLEEYVLQSRHRQTPFSLLILDVDYFKQI
NDAHGHLTGDRVLVQLADSLRSLCREGDFLARWGGEEFVILLPETQLSICVAVAEQLRQD
IAAQKFDGQSLTISLGAAQLREDDTTKTLVNRADNALYQAKHTGRNRVVAEAASPHIRAV
ND