Protein Info for Shew_2955 in Shewanella loihica PV-4

Annotation: ornithine cyclodeaminase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 54% identical to PY2CR_COLP3: Delta(1)-pyrroline-2-carboxylate reductase (lhpI) from Colwellia psychrerythraea (strain 34H / ATCC BAA-681)

KEGG orthology group: K01750, ornithine cyclodeaminase [EC: 4.3.1.12] (inferred from 100% identity to slo:Shew_2955)

Predicted SEED Role

"Ornithine cyclodeaminase (EC 4.3.1.12)" in subsystem Arginine and Ornithine Degradation (EC 4.3.1.12)

MetaCyc Pathways

L-ornithine degradation I (L-proline biosynthesis) (1/1 steps found)
L-arginine degradation VII (arginase 3 pathway) (1/2 steps found)
L-proline biosynthesis II (from arginine) (1/2 steps found)

KEGG Metabolic Maps

Arginine and proline metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.3.1.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QH73 at UniProt or InterPro

Protein Sequence (314 amino acids)

>Shew_2955 ornithine cyclodeaminase (RefSeq) (Shewanella loihica PV-4)
MQVIDAEAVHQALDFPSLTAALRDTFAQPAGMPQRQVFPLDDSSHSDAFAVLPAWNQKTI
AVKAFTYFPGNPKKSPELESLYSKILIFNRETGEPQALVDGTSVTYWRTAAISALASQYL
SRSDAKHLLLFGTGRLATFMALAHASVRQLKTITVWGRSPDKVDKTISAIQAAAPQIEVK
ACEDLPKAVAAADIISCATGAPAPLFDSAWVAPGTHVDLVGNHNHDRRECDSELVVKAEV
YVDAKVNVFAEAGELLIPVSEGVFELSQVKGELADLCRGDIPGRQGEQGITLFKSVGTAL
ADLVGAQLVYEKQA