Protein Info for Shew_2852 in Shewanella loihica PV-4

Annotation: aminoacyl-histidine dipeptidase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 486 TIGR01893: Xaa-His dipeptidase" amino acids 7 to 482 (476 residues), 604.7 bits, see alignment E=5.7e-186 PF01546: Peptidase_M20" amino acids 72 to 480 (409 residues), 58.4 bits, see alignment E=9.7e-20 PF07687: M20_dimer" amino acids 208 to 292 (85 residues), 50 bits, see alignment E=2.6e-17

Best Hits

KEGG orthology group: K01270, aminoacylhistidine dipeptidase [EC: 3.4.13.3] (inferred from 100% identity to slo:Shew_2852)

Predicted SEED Role

"Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3)" (EC 3.4.13.3)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.13.3

Use Curated BLAST to search for 3.4.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QGX0 at UniProt or InterPro

Protein Sequence (486 amino acids)

>Shew_2852 aminoacyl-histidine dipeptidase (RefSeq) (Shewanella loihica PV-4)
MSTLSQLQPQALWQWFEQICAIPHPSKHEQALSQYIQNWAKDKQLSVVEDKVGNLIIKKP
ATPGMENRKIVALQAHIDMVPQKNADKVHDFEKDPIEAYVDGEWVKAKGTTLGSDNGIGM
ASVLAILGSDDIPHGPLEVLLTIDEEAGMTGAFGLEAGYLDAEILINTDSEQEGEIYMGC
AGGVDAQITVPMVWQAAEPSLSTYTLTLSGLKGGHSGVNIHLGRGNANKLLARFLFNHAD
ELALELTNFSGGSLRNAIPREASVSFMLPSENLPRLETLIQEYTDLVRQELAIADPDMLL
TLSEIPAATQVMSEATQQTLIDLLNACPNGVMRMSDEIQGVTETSLNVGVITTEAESVSI
LCLIRSLIDSGREEVEGYLTALSNLAGAEVEFSGAYPGWKPDSSSPVMAIVKDTYESIYN
KEPVIMVIHAGLECGLFKKPYPEMDMVSIGPTIRFPHSPDEMVLIETVEQYWKLLLAVLE
RIPEKA