Protein Info for Shew_2851 in Shewanella loihica PV-4

Annotation: peptidase M17, leucyl aminopeptidase domain-containing protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 510 PF00883: Peptidase_M17" amino acids 174 to 489 (316 residues), 216.7 bits, see alignment E=2.4e-68

Best Hits

KEGG orthology group: K01255, leucyl aminopeptidase [EC: 3.4.11.1] (inferred from 100% identity to slo:Shew_2851)

Predicted SEED Role

"Cytosol aminopeptidase PepA (EC 3.4.11.1)" (EC 3.4.11.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.1

Use Curated BLAST to search for 3.4.11.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QGW9 at UniProt or InterPro

Protein Sequence (510 amino acids)

>Shew_2851 peptidase M17, leucyl aminopeptidase domain-containing protein (RefSeq) (Shewanella loihica PV-4)
MTGVQFIDVTDSEAIFDDNQWDAVVLVTHGLDAIAQEELAMLASHGAQVDARVGRSTTLL
FAPGLAGGRLIVAPVADGDSDIQDVRGYSDAARQGIKVAFDAGARRPLLIVTPSTQARYA
QSMGVAALGCAQALWQSLERREVLGEMDNISQIGLLVDDKAGELLCAIEAGKHLARDLCG
TEPERMSAPAFAQYCVDALEGLDLTMSVVEDRDVLERDYPLLSAVGRASFAVSRHQPRVV
KLEYKAEGPIERSYFFAGKGVVYDTGGADLKVGGAMAGMSRDKGGAAAVAGLMKTLALLK
PKGVRVVAELGLVRNSIGSEAFVTDEIITSHAGVRVRIGNTDAEGRLVLADLLSHLRLKA
QDAVAPQLFSVATLTGHVVRAYGGYTAVVENAVARQQQVGDSLQTISEAWGEPIEVSRLR
RDDYQKIVDPSGAADVLSSNNAPSSVTARGHQYPAAFLLKASGLEAHGLTSDKPLAYTHV
DIAGSATEGDPLYGTPTAAPLVSLCQLIRG