Protein Info for Shew_2817 in Shewanella loihica PV-4

Annotation: nucleoside transporter (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 419 transmembrane" amino acids 6 to 22 (17 residues), see Phobius details amino acids 31 to 51 (21 residues), see Phobius details amino acids 87 to 111 (25 residues), see Phobius details amino acids 166 to 186 (21 residues), see Phobius details amino acids 192 to 210 (19 residues), see Phobius details amino acids 252 to 277 (26 residues), see Phobius details amino acids 279 to 279 (1 residues), see Phobius details amino acids 285 to 304 (20 residues), see Phobius details amino acids 311 to 313 (3 residues), see Phobius details amino acids 315 to 331 (17 residues), see Phobius details amino acids 358 to 383 (26 residues), see Phobius details amino acids 394 to 418 (25 residues), see Phobius details TIGR00804: nucleoside transporter, NupC family" amino acids 4 to 416 (413 residues), 502.3 bits, see alignment E=5.3e-155 PF01773: Nucleos_tra2_N" amino acids 8 to 81 (74 residues), 90.7 bits, see alignment E=1e-29 PF07670: Gate" amino acids 92 to 189 (98 residues), 70.5 bits, see alignment E=2.2e-23 PF07662: Nucleos_tra2_C" amino acids 194 to 414 (221 residues), 264.5 bits, see alignment E=1.1e-82

Best Hits

Swiss-Prot: 66% identical to Y519_HAEIN: Uncharacterized transporter HI_0519 (HI_0519) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K03317, concentrative nucleoside transporter, CNT family (inferred from 100% identity to slo:Shew_2817)

MetaCyc: 49% identical to putative nucleoside transporter (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Na+ dependent nucleoside transporter NupC"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QGT5 at UniProt or InterPro

Protein Sequence (419 amino acids)

>Shew_2817 nucleoside transporter (RefSeq) (Shewanella loihica PV-4)
MDILMSLVGVVVLLAIGFLLSNNKKAINMRTVFGALAIQAFFAGFVLYVPIGKDILKSVS
DGVSSVIGYAQNGIGFLFGDLANFKVGFIFAINVLPVIVFFSSLIAVLYYLGIMQWIIRI
IGGGLQKALGTSRTESMSATANIFVGQTEAPLVVRPFIATMTQSELFAIMVGGLASIAGS
VLAGYAQMGVPIEYLVAASFMAAPGGLLMAKLMHPETEKTVNEMDELPEDPDKPANVLDA
AAAGASSGMHLALNVGAMLLAFVGLIAMINGIIGGVTGLFGAEGITLELILGYIFMPLAF
LIGVPWNEALIAGSFIGQKIVVNEFVAYLNFAPYLKDVADGGLLVEATNAVMTDRTKAII
SFALCGFANLSSIAILLGGLGAMAPTRRHDLAKLGIRAVIAGSLANLMSATLAGLFLAL