Protein Info for Shew_2795 in Shewanella loihica PV-4

Annotation: xanthine/uracil/vitamin C permease (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 452 transmembrane" amino acids 35 to 57 (23 residues), see Phobius details amino acids 64 to 84 (21 residues), see Phobius details amino acids 90 to 109 (20 residues), see Phobius details amino acids 115 to 135 (21 residues), see Phobius details amino acids 147 to 172 (26 residues), see Phobius details amino acids 184 to 202 (19 residues), see Phobius details amino acids 209 to 231 (23 residues), see Phobius details amino acids 252 to 273 (22 residues), see Phobius details amino acids 337 to 357 (21 residues), see Phobius details amino acids 360 to 381 (22 residues), see Phobius details amino acids 392 to 421 (30 residues), see Phobius details amino acids 430 to 451 (22 residues), see Phobius details PF00860: Xan_ur_permease" amino acids 32 to 412 (381 residues), 244.4 bits, see alignment E=8.9e-77

Best Hits

Swiss-Prot: 73% identical to GHXQ_ECOLI: Guanine/hypoxanthine permease GhxQ (ghxQ) from Escherichia coli (strain K12)

KEGG orthology group: K06901, putative MFS transporter, AGZA family, xanthine/uracil permease (inferred from 100% identity to slo:Shew_2795)

MetaCyc: 73% identical to guanine/hypoxanthine transporter GhxQ (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-562; TRANS-RXN0-578

Predicted SEED Role

"Xanthine/uracil/thiamine/ascorbate permease family protein" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QGR3 at UniProt or InterPro

Protein Sequence (452 amino acids)

>Shew_2795 xanthine/uracil/vitamin C permease (RefSeq) (Shewanella loihica PV-4)
MKSEQTLAAPAVHASSLLDRYFAITARGSTLRQEVIAGLTTFLAMVYSVIVVPNMLGAAG
FDPGAVFVATCLIASFGSLLMGLWANLPMAIGCAISLTAFTAFSMVLGQGISIPVTLGAI
FLMGVVFTLVSVTGVRQWVLTNLPKGIAHGTGIGIGLFLLLIATNSVHLIVANDAGLPVK
LGDIHSLPVIATVIGLAATIGLERRGVPGGILLVIIALSVFGLAFDPSVTYQGLFALPDL
MSDKSLIGQLDIMGALNPVVLPIVLALVMTAIFDATGTIRAVAGQAELLDEKDNIVGGGK
ALTSDSMSSIFAGAVGGAPAAVYIESAAGTAAGGKTGLTATIVGVLFLLMVFLAPLSYLV
PAYATAPALMYVGLLMLSNVTKLNFDDKVDAMAGLTCAVFIILSCNIVTGIMLGFVTLVV
GRLASGEWRALKPGVLAITIGLVVFYMGGWAI