Protein Info for Shew_2575 in Shewanella loihica PV-4

Annotation: 3-oxoacid CoA-transferase, A subunit (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02429: 3-oxoacid CoA-transferase, A subunit
  • amino acids 4 to 218 (215 residues), 259.9 bits, E=8e-82
• PF01144: CoA_trans
  • amino acids 9 to 217 (209 residues), 255.4 bits, E=1.9e-80

Best Hits

Swiss-Prot: 61% identical to SCOA_HELPJ: Succinyl-CoA:3-ketoacid coenzyme A transferase subunit A (scoA) from Helicobacter pylori (strain J99 / ATCC 700824)

KEGG orthology group: K01028, 3-oxoacid CoA-transferase subunit A [EC: 2.8.3.5] (inferred from 100% identity to slo:Shew_2575)

MetaCyc: 60% identical to succinyl-CoA-transferase subunit A (Helicobacter pylori 26695)
3-oxoacid CoA-transferase. [EC: 2.8.3.5]

Predicted SEED Role

"Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A (EC 2.8.3.5)" in subsystem Catechol branch of beta-ketoadipate pathway or Leucine Degradation and HMG-CoA Metabolism or Protocatechuate branch of beta-ketoadipate pathway or Serine-glyoxylate cycle (EC 2.8.3.5)

MetaCyc Pathways

• TCA cycle VI (Helicobacter) (7/9 steps found)
• ketolysis (2/3 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Synthesis and degradation of ketone bodies
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 2.8.3.5

Use Curated BLAST to search for 2.8.3.5

Sequence Analysis Tools

See A3QG43 at UniProt or InterPro

Protein Sequence (233 amino acids)

>Shew_2575 3-oxoacid CoA-transferase, A subunit (RefSeq) (Shewanella loihica PV-4)
MAGLNKLVTSYEEALEGLTDNMTVMVGGFGLCGIPEGLIAQMVKSGAKGLTAISNNAGVD
DFGLGLLLKSRQISTMIASYVGENATFEQQMLSGELNVILTPQGTLAEKIRAGGAGIPAF
FTATGYGTPVAEGKETREIDGRHYVLEPALTADFALVRAWKADTMGNLVFRKTAANFNPM
MATAGKITVVEAEHIVEPGELDPDHIHTPGIYVDRLIQGTFEKRIEQRTVKSK