Protein Info for Shew_2504 in Shewanella loihica PV-4

Annotation: PpiC-type peptidyl-prolyl cis-trans isomerase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 621 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details PF13624: SurA_N_3" amino acids 1 to 165 (165 residues), 162.7 bits, see alignment E=2e-51 PF13623: SurA_N_2" amino acids 2 to 141 (140 residues), 128.5 bits, see alignment E=5.8e-41 PF13145: Rotamase_2" amino acids 249 to 379 (131 residues), 81.7 bits, see alignment E=2.4e-26 PF13616: Rotamase_3" amino acids 262 to 365 (104 residues), 100.8 bits, see alignment E=2.3e-32 PF00639: Rotamase" amino acids 275 to 364 (90 residues), 89.2 bits, see alignment E=9e-29

Best Hits

KEGG orthology group: K03770, peptidyl-prolyl cis-trans isomerase D [EC: 5.2.1.8] (inferred from 100% identity to slo:Shew_2504)

Predicted SEED Role

"Peptidyl-prolyl cis-trans isomerase PpiD (EC 5.2.1.8)" (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QFX2 at UniProt or InterPro

Protein Sequence (621 amino acids)

>Shew_2504 PpiC-type peptidyl-prolyl cis-trans isomerase (RefSeq) (Shewanella loihica PV-4)
MLEKIREGSQGVIAKGILVLVILSFAFTGVSSYLGSSSEPSAATVNGEEISKSALEQAYQ
SERARLEQQLGDMYDTLASNESYLASVKQNVLERLIADKLVDQAAADLGLTVSDQQIKTA
IMNEPAFQTDGKFDNDRYLALIRQLGYQANSFRDMMRGDMTRRQLVVTVVGSEFVLPGEA
EYLAKIQGQTRDIRYHVVDAEPMLATVSVSDEEANTYYQQNQSLFVRPETISLDYIELSA
NQLASAIQVSDEEAKTYYDENKAQYLQPEKRLAAHILVSLGDDEDAAKAKAEAIMTKLKA
GEDFEALAKSDSDDSFSGEQGGKLDWFEQGVMEAPFDQALFALEKGQYSDIVKTSFGYHI
IKLLDLQAASTSPFEAVKDKIVAQIQQDKAVNEFYTLQQRLSDVSYEVPDTLAEAAKEVG
VAVKTSPVFTRDNAPEPLNSADVLKAAFSNTVLLDGMNSDVIELGDNHVVVVRVNKHAAA
GTMEFADVKATIVERLKQDKANELARDKAQEMMAAIKGGEIPAEMITRTQLSRGEQGIDT
SIVSKAFEMAQPAEQFVVDTAALANGYAVVILDKVNQAESVDESLVTALKQRLNSQYSEN
DYRALIAALKAQAEVVYTPAE