Protein Info for Shew_2342 in Shewanella loihica PV-4

Annotation: integral membrane sensor signal transduction histidine kinase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 544 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 232 to 257 (26 residues), see Phobius details PF00512: HisKA" amino acids 318 to 378 (61 residues), 28.9 bits, see alignment E=1.5e-10 PF02518: HATPase_c" amino acids 424 to 526 (103 residues), 71.6 bits, see alignment E=1.1e-23

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_2342)

Predicted SEED Role

"Sensor histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QFG0 at UniProt or InterPro

Protein Sequence (544 amino acids)

>Shew_2342 integral membrane sensor signal transduction histidine kinase (RefSeq) (Shewanella loihica PV-4)
MSIKGYLFVLFGALILILGGSQLLVSHFYKAQLQSELSERSRDLSQNLVKVLIDNVGTEQ
EFVVQFDEQALQESLQDAEALRQEFEQDIESVSQAIAQLSEEVVRMEMETDNASAEQKAF
FRAKLAAKQQELRDHLNAMMSYEKELKQRQRASIAEAKREAADEYRRRLHDAVSHIEIDT
NSWLDKGNVAIIDAPISPTTPEKGKVAVEFAHDINLPNQETNEQLERFSESMIGAILMSS
LAGLLLVYMLSHVISAPLSALAKGHKKLGQGELGYQVDERGVKELKSILNGFNKMSSQLA
SLSEQKKQMAQQKQLAELGEVTRGIAHSLRNPLHTLGLLSEAVAQSESIEDANKLLSQMQ
QKIAMMDKSIQSLLTLSSTQVNRQSWVPLAATVQDILLELSINGSKPSIAFHCEDQGIQV
QGAESEIRSILHAVVINAVEATPDTGRIDLTLAEDDESYTLVVADTGKGISPEVRDKLAQ
PHVTTKAEGTGMGIYIAERLIQGHYGGRITFDDNPGGGTLVTLYFAKPDSNKTQQEDKPQ
TEEV