Protein Info for Shew_2232 in Shewanella loihica PV-4

Annotation: heat shock protein 90 (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 639 PF02518: HATPase_c" amino acids 29 to 183 (155 residues), 34.3 bits, see alignment E=4.3e-12 PF13589: HATPase_c_3" amino acids 30 to 157 (128 residues), 42.4 bits, see alignment E=1.1e-14 PF00183: HSP90" amino acids 222 to 638 (417 residues), 439.9 bits, see alignment E=2.4e-135

Best Hits

Swiss-Prot: 100% identical to HTPG_SHELP: Chaperone protein HtpG (htpG) from Shewanella loihica (strain ATCC BAA-1088 / PV-4)

KEGG orthology group: K04079, molecular chaperone HtpG (inferred from 100% identity to slo:Shew_2232)

MetaCyc: 68% identical to chaperone protein HtpG (Escherichia coli K-12 substr. MG1655)
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10, 5.6.1.7]

Predicted SEED Role

"Chaperone protein HtpG" in subsystem Protein chaperones

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.4.10 or 5.6.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QF50 at UniProt or InterPro

Protein Sequence (639 amino acids)

>Shew_2232 heat shock protein 90 (RefSeq) (Shewanella loihica PV-4)
MSHQETHGFQTEVKQLLNLMIHSLYSNKEIFLRELVSNAADAADKLRYEALTKDELYEGD
GELRVRVSADSEKGTVTIEDNGIGMTRDGVIEHLGTIAKSGTAEFFKNLSGDESKDSQLI
GQFGVGFYSAFIVADKVTVRTRAAGHAADEAVQWESAGEGEFTVENIVKESRGTEIILHL
REEEKEFASDYRLRSIITKYSDHISVPVEMWQEGTPAQEATEEGGEAIPATEGHWKAMNK
ATALWTRNKSDVTDEEYQEFYKHISHDFADPLLWSHNRVEGKQEYTSLLYIPSKAPWDLW
NRDRKHGLKLFVQRVFVMDDAEQFMPSYLRFVQGLIDSNDLPLNVSREILQDNKITTALR
TAVTKRVLGMLEKLAKNDPEKYQTFWAEFGQVLKEGPAEDFANKEKIAGLLRFASTHTNE
AAHTVSLSDYVERMKEGQSKIYYIVADSHEAAANSPHLELLRKKGIEVLLMSERIDEWLI
NHLSEFDGKQLHSVTRGDLELGELEDAAEKEAQEKLETESEGLVKRVKEVLGDKVAEVKV
TSRLTDTPACVVAGAGEMSSQMIKLMQAAGQAVTESKPVFELNPEHPLVKRLDTEQDEEV
FGQWAELLLQQAQLSEKGSLADPSAFIKLMNKMLLASVK