Protein Info for Shew_2198 in Shewanella loihica PV-4

Annotation: histidinol dehydrogenase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 443 PF00815: Histidinol_dh" amino acids 37 to 435 (399 residues), 539.9 bits, see alignment E=2.3e-166 TIGR00069: histidinol dehydrogenase" amino acids 43 to 434 (392 residues), 521.1 bits, see alignment E=1.1e-160

Best Hits

Swiss-Prot: 77% identical to HISX_SHEON: Histidinol dehydrogenase (hisD) from Shewanella oneidensis (strain MR-1)

KEGG orthology group: K00013, histidinol dehydrogenase [EC: 1.1.1.23] (inferred from 100% identity to slo:Shew_2198)

MetaCyc: 59% identical to histidinal/histidinol dehydrogenase (Escherichia coli K-12 substr. MG1655)
Histidinol dehydrogenase. [EC: 1.1.1.23]

Predicted SEED Role

"Histidinol dehydrogenase (EC 1.1.1.23)" in subsystem Histidine Biosynthesis (EC 1.1.1.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QF16 at UniProt or InterPro

Protein Sequence (443 amino acids)

>Shew_2198 histidinol dehydrogenase (RefSeq) (Shewanella loihica PV-4)
MTTNTMTSTQMQRLDWQALNDQARREALSRSPLIGDANLEQQVKAIIDQVASQGDVALKA
FSQKFDKVELDALRLSDAAIAAASERVTPEIKAAIEQAKQNIETFHQAQAFKGIDLETQA
GVRCELRSEPIEKVGLYIPGGSAPLISTVLMLALPAKIAGCEQRVLVSPPPIDDAIVYAA
KACGITDIYQIGGAQAIAALAQGTESVPAVDKIFGPGNRYVTEAKRLVAQDSRCVVSIDM
PAGPSEVLVIADNEANPDFIAADLLSQAEHGPDSQVMLVTDSQTLADAVNQSLGEQLARL
PRAEIAMQALSASRTLIVEDMAQAAEVSNRYGPEHLIIQTRAPRKLLSKIRAAGSVFLGA
YTPESVGDYASGTNHVLPTYGYSRAVSSLSLADFSRRFTVQELSAEGLRGLGECVMTLAS
AEQLDAHRNAVAVRLATLTGEEK