Protein Info for Shew_2131 in Shewanella loihica PV-4

Annotation: exodeoxyribonuclease V, alpha subunit (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 662 TIGR01447: exodeoxyribonuclease V, alpha subunit" amino acids 12 to 659 (648 residues), 560.6 bits, see alignment E=2.3e-172 PF21185: RecD_N" amino acids 14 to 117 (104 residues), 48.6 bits, see alignment E=3.3e-16 PF13245: AAA_19" amino acids 165 to 321 (157 residues), 118.4 bits, see alignment E=1.1e-37 PF13604: AAA_30" amino acids 167 to 365 (199 residues), 98.6 bits, see alignment E=1.6e-31 PF05127: Helicase_RecD" amino acids 179 to 303 (125 residues), 33.5 bits, see alignment E=1.6e-11 PF01443: Viral_helicase1" amino acids 580 to 631 (52 residues), 22.3 bits, see alignment 4.1e-08 PF13538: UvrD_C_2" amino acids 584 to 630 (47 residues), 41 bits, see alignment 5.6e-14

Best Hits

KEGG orthology group: K03581, exodeoxyribonuclease V alpha subunit [EC: 3.1.11.5] (inferred from 100% identity to slo:Shew_2131)

Predicted SEED Role

"Exodeoxyribonuclease V alpha chain (EC 3.1.11.5)" in subsystem DNA-replication (EC 3.1.11.5)

Isozymes

Compare fitness of predicted isozymes for: 3.1.11.5

Use Curated BLAST to search for 3.1.11.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QEU9 at UniProt or InterPro

Protein Sequence (662 amino acids)

>Shew_2131 exodeoxyribonuclease V, alpha subunit (RefSeq) (Shewanella loihica PV-4)
MIQLAQPLSQLLKHWQQEGLLTPLDRHFALQMQALHSDGDDLFTLICALLSRQLSQQHTC
LPLTQIDKNNPLHEQQPQCQLELTPQALAGQLTQYQAISPADGELNTPLILDGDRLYLQR
YYQFETQVAERLTRLNQPITVAAPDKVACILNILFAGQAEKPDWQKVATATAFSQKLAVI
TGGPGTGKTTTVTKLLLLLCLEQQLTIKLVAPTGKAAARLSESIKASKARLAQELAPYGD
ELDLEQLKQVPEEAATLHRLLGVIPGSHRFRHHKDNPLRLDLLILDEASMVDLPMMHKLL
EALPEHTRLILLGDQDQLASVEAGAVLADICAGLKQTSSQESGWRMRYSQEKAALLSQLT
NEDLSNYIDARPALGDSLAMLMHSHRFKGDAGIGQLAGAVNRRDLTGILSVWQKGYDELS
WLEHQLSPQGNAGLKALMAQSVDKYRPYLDLVGHLANKEQAQEVDKEADQQLDLDEIANQ
IITRFNNFRILCAMRAGEYGVEGINAAVTQALKDAQLIQPSSEFYAGRPIIIQSNDYNLG
LFNGDIGVILPGHGPTHRLMAYFVQADGSLLKVLPARLPSHETCYAMTVHKSQGSEFQQV
AFVLPPRPSVAQRQLLTKELVYTAITRAKGHFSCLGSQAVFEAACSQVTLRASGLAQRLW
PA