Protein Info for Shew_2130 in Shewanella loihica PV-4

Annotation: exodeoxyribonuclease V, beta subunit (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1223 TIGR00609: exodeoxyribonuclease V, beta subunit" amino acids 6 to 1176 (1171 residues), 982.5 bits, see alignment E=1.9e-299 PF00580: UvrD-helicase" amino acids 11 to 162 (152 residues), 81.1 bits, see alignment E=2.4e-26 amino acids 336 to 439 (104 residues), 81.2 bits, see alignment E=2.1e-26 PF13245: AAA_19" amino acids 17 to 428 (412 residues), 49 bits, see alignment E=1.4e-16 PF13361: UvrD_C" amino acids 446 to 813 (368 residues), 76.9 bits, see alignment E=4.1e-25 PF12705: PDDEXK_1" amino acids 950 to 1178 (229 residues), 23.8 bits, see alignment E=8.2e-09

Best Hits

Predicted SEED Role

"Exodeoxyribonuclease V beta chain (EC 3.1.11.5)" in subsystem DNA-replication (EC 3.1.11.5)

Isozymes

Compare fitness of predicted isozymes for: 3.1.11.5

Use Curated BLAST to search for 3.1.11.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QEU8 at UniProt or InterPro

Protein Sequence (1223 amino acids)

>Shew_2130 exodeoxyribonuclease V, beta subunit (RefSeq) (Shewanella loihica PV-4)
MATQTLDPLSLPLSGTRLIEASAGTGKTYTIAGLYVRLLLGDSQRAPLSCEQILVVTFTN
AATQELRDRIRKKIQLAYRAFLGMEVDDPLINTLYSEAEPEARSQALKRLDLALKSLDEA
AIFTIHGFCQRILSDMAFESSLLFESEFTLDDSEYLHHAVRDFWREACYPLPGYLAQIIS
NKFSDPDGLTKQLRPLLGANQASVSPTPEAFSQVAERLSQSLSRLRLIWPRERDATLELL
KALPLNGTRFGKKDQGYPKLETLFAAMDNWAAQPLSLPDNKVLGALALGGLKLNKGGESP
TPEQAPLLAHIERVTETIDTLVPSFLYGARDGIKARFAAQKQLKNLRTPDDLLIALADAL
SEETDQEQALARAIAKRFPIALIDEFQDTDPLQYQIFSSIYQGQQVSTDSDLGLLMIGDP
KQAIYAFRGADIHTYIHARGQTENHYSLDTNYRSSQAMIEAVNQLFSRSDDPFISQAIPF
ELVKASPEAAEKRLVEKVPQTSALRLKLLGEDPNAGLNKASARSQLAEDAANEIARLLNE
AQRGECLKQDKPLKAKDIAVLVRDRNEAAYIKTALSSRGIGAVFLSRDSVFDTLVAKELA
LVLLAIANPKDERALRSAMATALLGYDAQAIHGFNLDEDVRQQQLEAFDNLHQTWLKRGI
MPCMMALAADTRLIERLLTADEGQRRLTDFRHLGELLQQKAMELDGISALLNWYQQTLIE
VSSTEEAQLRLESEQNLVQIVTIHKSKGLEYPICFLPFVSLARDSRRKPAPMLYHEQDAL
VWDIDQSEEGWAKYKAENLAEDLRLLYVALTRPVLACYCYVANHSRFTKRDGISSQLFET
AIGYLLGIETNACEFADIQAAAQALASEAISVDLVESDAPKLDFDPIDTADAVKLAPRPL
NRRHEIPWRVGSYSGLVKHSAHEQISPGMGDEAFPELEQLAPDSEQLSRFSFERGANAGS
FLHWVLEQIDFTLADTSLGDELPKAMERFGIDSEWQDMLHAWYLDLLHTPLDGDGLRLAS
LSQAQKLVEMEFYMPIGKLDAPGLNQLLSQYGYSAALNFETLEGMLKGFIDLTFEYQGKF
YIADYKSNHLGDHLSHYEKPAMLRAIAGHHYDLQYIIYSLALHRYLKLRLPGYQYDQHVG
GCYYLFLRGMSADSPSTGVYYDKPPLALIQALDTLLSEAEASESQAESKAESQAEPQAEP
ESHSQADRQSDMPSGPAQGELDL