Protein Info for Shew_2121 in Shewanella loihica PV-4

Annotation: diguanylate cyclase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 452 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 169 to 191 (23 residues), see Phobius details PF00672: HAMP" amino acids 194 to 237 (44 residues), 30.7 bits, see alignment 3.2e-11 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 265 to 426 (162 residues), 155.9 bits, see alignment E=3.9e-50 PF00990: GGDEF" amino acids 268 to 424 (157 residues), 155.3 bits, see alignment E=1.2e-49

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_2121)

Predicted SEED Role

"GGDEF family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QET9 at UniProt or InterPro

Protein Sequence (452 amino acids)

>Shew_2121 diguanylate cyclase (RefSeq) (Shewanella loihica PV-4)
MMINTRLKLLLFISLFLTTTILLTFAGLKHIQQENLQQLSHIMQLESSIDVLRSRLWALQ
EFQDEEVLTQTLNAHQQLKAKLAEAQFLAPATKVLTTNLNRQADSLAALLKLTQQHMSSP
PQRGITSARGMLTTRFNITIQSMSEDLTSLQRLVIDSLAEQQSQILSSTILFLLAGSVIS
LLVTMSTLKAFRESLHRMKMGISKLSQGDLDSHIEIVHQNELAILAQKFNTMTHKLKETT
IRKEALQGEVAAQTKQLKRQTQKLKYVAEHDDLTGLYSRSAFERQIDTAIARCQRTQMHA
AMLFIDLDKFKQVNDSLGHDNGDKVLSTAARRMQSAVRSSDICGRLGGDEFVVWLEPIND
IEEVTIVIDKIIRQISPPIVCGRTTVSLTVSIGVAMYPRDELTRLSLIKVADDNMYQAKQ
VKGNSHRFTEQVARQVDKRQVDESQIDETQVG