Protein Info for Shew_2080 in Shewanella loihica PV-4

Annotation: diguanylate cyclase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 934 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 734 to 752 (19 residues), see Phobius details PF00497: SBP_bac_3" amino acids 32 to 249 (218 residues), 115.8 bits, see alignment E=2.1e-37 amino acids 257 to 471 (215 residues), 76.6 bits, see alignment E=2.2e-25 amino acids 502 to 720 (219 residues), 120.6 bits, see alignment E=7.4e-39 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 772 to 927 (156 residues), 126.6 bits, see alignment E=4e-41 PF00990: GGDEF" amino acids 775 to 928 (154 residues), 140.7 bits, see alignment E=3.8e-45

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_2080)

Predicted SEED Role

"Signaling protein with a periplasmic binding domain and GGDEF domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QEP8 at UniProt or InterPro

Protein Sequence (934 amino acids)

>Shew_2080 diguanylate cyclase (RefSeq) (Shewanella loihica PV-4)
MIARFVMGTAALTLSLMLSFQVSAEEQQAPLVLVMGEDSYPYQFVDENGDVKGVLVDLWR
EWSSQTQVPVVFVARHWQDSLKQLAQGDADIHIGLGITKERDKDFDFAAPIAYVSTYLYV
RNTLKGKKSFSDLQPYRIGIVTGSSHESILNQQVNGLSYRYYNSRAELLRGVVAGEVDVF
AGMEGYLKDNAVSRAVLEEFPLDNRLLIKKTALVPAVSKGRLDLITEINRGFDRLSQTSR
AEIDKRWLGFSHDANTLVIATTTGIQPFVDTGGDGEPHGLYIDIWKLWSKKTGIEVEFRP
AAMEDGLDELKFHRADIHVGYPESDTMKTNLTRAWRTYQVKSRLFSYGKAINSLDELKGK
RVGAVPTAPYLDKLKQALPNSELKLYTDVTQMIQAAQQGHIAAFVAASAWTQHYLLRAES
WSDFHQYRKLAFTTDIYALTRNEDKGLAQRIAAGFRLISNAELAAIENKWILDRDDRSVQ
SLLNPLAITEEQRRYLDSLGTLKVGYLAAWAPMEYQGPSGEFMGINSEISHWVAEQLGLT
IEGVPFDRWSSLLEALKQGEIDIVGSVAHTPEREREMLFTTPYWPSPWGLVTNLSQVTVF
NLSQMSGKRLAIVEGYHLIANLMNKALGIELVIVPNSRAGVDAVAQGKADAFIEKVINMA
MVLKESDYKALKMSVLADFSQQQSHFALSPKFAALVPLWDQAIAQITPERQEEIYQHWVK
EEPSSWKTWVNYQSAFYLLALLSFVVFVYLIWRAQRSRLAAAKELAHELTRAGQFDALTG
LPNRSLLDDRLQQSVLIHRREMQPFAVLFISFDNMREINQTYGHQVGDRVLAKGAQRLKS
AVRKSDTLARFGGNEFVMVLNRSKDLDTVCQVADGIVGGFSAPFAINGLDVALSVSIGVA
MFPSDGDTVVELLKTADKLMSRAVKQGGRCYQSA