Protein Info for Shew_1976 in Shewanella loihica PV-4

Annotation: putative ATP-dependent protease La-relatedprotein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 PF20437: LonC_helical" amino acids 90 to 123 (34 residues), 52.3 bits, see alignment (E = 8.9e-18) PF13654: AAA_32" amino acids 320 to 450 (131 residues), 170 bits, see alignment E=5e-54 PF20436: LonB_AAA-LID" amino acids 478 to 542 (65 residues), 74.2 bits, see alignment E=1.4e-24 PF05362: Lon_C" amino acids 651 to 756 (106 residues), 40.2 bits, see alignment E=5.9e-14

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_1976)

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type II" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.53

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QEE4 at UniProt or InterPro

Protein Sequence (800 amino acids)

>Shew_1976 putative ATP-dependent protease La-relatedprotein (RefSeq) (Shewanella loihica PV-4)
MSISPLASDKLYRSSTLALLDPSIKSTKQLTPLNEIVGQERAQQAVEFAMSMKDKGYNIY
AIGRNGLGKRTMVMRYLDRYDPNGHHQLFDWCYVVNFDDARTPKVLKLPRGQAQAFKADI
ENLMKRLVKALPLAFDNELYYSRAEKLKAQLADKQESALGQITKEAAAKQISLSINPQGS
YELVAMNGEEPHTESSFAELSAKEQARLEKNIGSLESKLREVVRKFTAWEESYSDKQQKH
DEQVAQEVLVHLLEPLKESYAQYPEVKAHLNEMHKDILDNLDIFLEQNEEQIALSYASLA
KKMPRRYQVNVLVNHGDIPMPIVIEESPNYHNIFGYIENATYKGTIFSDFSLIRPGSLHK
ANGGVLMIDAIKVLEQPYVWDGLKRALRSRKLSLSSLEREVTLSGTISLDPEAIPLDVKI
ILFGDYQTYQLLQHYDPEFKELFRVTADFEDEMPRTDASEVQYAKFISSIVVGNKMLHCD
RGAIKRIIEFSARQADAQNKLSLHSADIANLLRESNYVARTSKSNMIRAGHVEQALHNHE
LRVCRLRDYVMQSFINGTTLIDTQDSVVGQINALSVVATSDHQFGAPSRITASVSLGEGA
VFDIERKVELGGQIHSKGVMILTAYLATIFGQTDKIPLTTHLTFEQNYSGVDGDSASMAE
LCAIVSAFAKVPLRQDVAITGSMNQFGQAQPIGGVNEKIEGFFDVCKIKGRHKGQGVIIP
RTNVQNLMLRADIVDAVNKGEFSIWAIEHVDQAVEILTGIPAGERDFEFEDYPKESLYAL
ADARLQKLRDHVKRTQKAKV