Protein Info for Shew_1924 in Shewanella loihica PV-4

Annotation: succinylglutamate desuccinylase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03242: succinylglutamate desuccinylase
  • amino acids 10 to 346 (337 residues), 363.6 bits, E=4.8e-113
• PF04952: AstE_AspA
  • amino acids 66 to 349 (284 residues), 252.8 bits, E=2.1e-79

Best Hits

Swiss-Prot: 72% identical to ASTE_SHESH: Succinylglutamate desuccinylase (astE) from Shewanella sediminis (strain HAW-EB3)

KEGG orthology group: K05526, succinylglutamate desuccinylase [EC: 3.5.1.96] (inferred from 100% identity to slo:Shew_1924)

Predicted SEED Role

"Succinylglutamate desuccinylase (EC 3.5.1.96)" in subsystem Arginine and Ornithine Degradation (EC 3.5.1.96)

MetaCyc Pathways

• L-arginine degradation II (AST pathway) (5/5 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.1.96

Sequence Analysis Tools

See A3QE92 at UniProt or InterPro

Protein Sequence (355 amino acids)

>Shew_1924 succinylglutamate desuccinylase (RefSeq) (Shewanella loihica PV-4)
MRDTLMLSKDFLQLTLDNPVGLEAFEFTLGQHTQVSVWDTGVIQFEPLVTYEANQESEQD
GKEEALKSIVLSSAVHGNETAPIELCDQLITALLSETLIARHRLLFLIGNPPAILNGTRF
VEENLNRLFSGAHAKGESNAERVRAKKLEQYVDRFFNAAPKDGSRYHYDLHTAIRASKHE
KFAIYPYPHGAPYSGEQIMFLAACGINTVLFHHEPTTTFSYFSAHGYQAHAFTIELGKVM
PMGQNDMTRFIAVKEMLTRLVSGRDLELGEFDPSQVNLYQVHRSINKQFDDFSFTFADDV
ENFTAFPRGYILAKDGGTEIKVEAESESIVFPNANVPVGQRTVLCLVPAKDYRVV