Protein Info for Shew_1898 in Shewanella loihica PV-4

Annotation: ApbE family lipoprotein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 330 transmembrane" amino acids 289 to 309 (21 residues), see Phobius details PF02424: ApbE" amino acids 73 to 321 (249 residues), 230.7 bits, see alignment E=1.1e-72

Best Hits

KEGG orthology group: K03734, thiamine biosynthesis lipoprotein (inferred from 100% identity to slo:Shew_1898)

Predicted SEED Role

"Thiamin biosynthesis lipoprotein ApbE"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QE66 at UniProt or InterPro

Protein Sequence (330 amino acids)

>Shew_1898 ApbE family lipoprotein (RefSeq) (Shewanella loihica PV-4)
MSPLADLDDQQAVISDESEYPFVDSQYGRKNLKGLRGEFMAMASRCELLARPKQAGSKAQ
DDKIDQERITQAFSRAMAEVKCIEAKYSRFSENSVLTQINRGAGDWQAIDDETLGLLKFA
EHCYRLSQGRFDVTAEPVLALWPFGAGESAAPPSDSKIEAALAQVGFERLIIEDNHFFLP
YGMGIDLGGIAKEYAADRAVEVLRRELPEYDLLVNLGGDMIASPGCERPWQIGIEDPHKL
DTPARVVTLKSGALATSGHSRRYLLHQGKRYGHIIDPSTGYPIKGAPISVSVFAPSCVVA
GMLATLAMLQGEGAEDFLSRQGVVHHIIRG