Protein Info for Shew_1391 in Shewanella loihica PV-4

Annotation: CheW protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 164 PF01584: CheW" amino acids 20 to 156 (137 residues), 141.4 bits, see alignment E=7.7e-46

Best Hits

Swiss-Prot: 34% identical to CHEW_KLEAK: Chemotaxis protein CheW (cheW) from Klebsiella aerogenes (strain ATCC 13048 / DSM 30053 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006)

KEGG orthology group: K03408, purine-binding chemotaxis protein CheW (inferred from 100% identity to slo:Shew_1391)

Predicted SEED Role

"Positive regulator of CheA protein activity (CheW)" in subsystem Bacterial Chemotaxis or Two-component regulatory systems in Campylobacter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QCR2 at UniProt or InterPro

Protein Sequence (164 amino acids)

>Shew_1391 CheW protein (RefSeq) (Shewanella loihica PV-4)
MADAKNVAAVAAGKDDEVLQWVTFRLDNETYGINVMQVQEVLRYTEIAPVPGAPHYVLGI
INLRGNVVTVIDTRSRFGLPSAEVDDSTRIVIIEAEKQVIGILVDSVAEVVYLRGSEIDN
APNVGTEESAKFIQGVSNRDNELLILVDLDKLLSDEEWMELAQL