Protein Info for Shew_1264 in Shewanella loihica PV-4

Annotation: UvrD/REP helicase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 678 transmembrane" amino acids 377 to 395 (19 residues), see Phobius details PF00580: UvrD-helicase" amino acids 6 to 261 (256 residues), 144.5 bits, see alignment E=1.3e-45 PF13245: AAA_19" amino acids 16 to 251 (236 residues), 62 bits, see alignment E=1.8e-20 PF13361: UvrD_C" amino acids 526 to 605 (80 residues), 67.5 bits, see alignment E=3.6e-22

Best Hits

KEGG orthology group: K03657, DNA helicase II / ATP-dependent DNA helicase PcrA [EC: 3.6.4.12] (inferred from 100% identity to slo:Shew_1264)

Predicted SEED Role

"putative DNA helicase"

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.12

Use Curated BLAST to search for 3.6.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QCD6 at UniProt or InterPro

Protein Sequence (678 amino acids)

>Shew_1264 UvrD/REP helicase (RefSeq) (Shewanella loihica PV-4)
MTKRLTWEQTRVVRHDAGHALIKAVPGSGKTTTLVKRVERLIKTGVEPGSILILMYNKSA
TVSFSDKLKLALKSDAIPEVRTFHSLALKIVALAERQQLTPKKMLITPGNYRYDELVKQA
YRVGCSYDSGYIEQSDITDFETFVSRCRASAVTPADAAADPTFSKIKPEFIRAYGCYCEL
LEANGLRTFEDSMIEAVSLLRIYPGLVARFKHIIVDEYQDVNLVQHEMIRLLTKPDTSVM
VVGDLNQCIYEWRGAQPDFMDGLFEQQFPNTTVFQLSCTFRFGHELSLIANSVIRRNSSK
LTRLCVSHPSTPKTEVKLHLDNCLSEVLSAIATENGSQAILSRSNARLTEVELVLRLCGR
TYRYLNGSSSLYSRSEIGLLVVGVLLCVYGDLRLIENHPCKREMLYGFLREAGIRWQKGQ
VKEALDALMTQVDVFSVLGRLFENSPHQRERLERLASVRNKDDDSVLASNVLQHLSLAGF
IEGVGSDSVRRTASNDRLRGVDRIEELLISNPIDARTFLNLILHPQDISADSEPITLATI
HGSKGLEWDHVILIGLNDCEFPGGKPDSGTQLPALTSESISNEELEVERRLFYVGITRAK
HQLHLVAPLDESLTWWLKKRWDSTPKKVPVATRFIYEAGLTACSLTSQSIYAGLLEQQTT
EFSKFHQWYLKDLQRLRV