Protein Info for Shew_1214 in Shewanella loihica PV-4

Annotation: DNA mismatch repair protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 855 TIGR01070: DNA mismatch repair protein MutS" amino acids 12 to 853 (842 residues), 1230 bits, see alignment E=0 PF01624: MutS_I" amino acids 13 to 124 (112 residues), 140.2 bits, see alignment E=7.9e-45 PF05188: MutS_II" amino acids 133 to 257 (125 residues), 117.7 bits, see alignment E=1.3e-37 PF05192: MutS_III" amino acids 274 to 563 (290 residues), 184 bits, see alignment E=1e-57 PF05190: MutS_IV" amino acids 432 to 521 (90 residues), 98.8 bits, see alignment E=4.6e-32 PF00488: MutS_V" amino acids 614 to 801 (188 residues), 301.1 bits, see alignment E=9.3e-94

Best Hits

Swiss-Prot: 68% identical to MUTS_CROS8: DNA mismatch repair protein MutS (mutS) from Cronobacter sakazakii (strain ATCC BAA-894)

KEGG orthology group: K03555, DNA mismatch repair protein MutS (inferred from 67% identity to enc:ECL_04080)

MetaCyc: 68% identical to DNA mismatch repair protein MutS (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"DNA mismatch repair protein MutS" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QC86 at UniProt or InterPro

Protein Sequence (855 amino acids)

>Shew_1214 DNA mismatch repair protein (RefSeq) (Shewanella loihica PV-4)
MNAVDTQYLEKHTPMMRQYLTLKAETPDMLLFYRMGDFYELFYDDAKRASELLGISLTAR
GKSGGDPIPMAGIPYHAVEGYLAKLVQLRVSVAICEQIGDPATTKGPVERKIVRIVTPGT
LTDEALLQERQDNLLAAVYHGKVGFGYATLDVSSGRFVVTELASKEALEAELQRTNPAEL
LYSEDFSEPALIASLSGKRRRPEWEFDYDTSYKLLLEQFGTKDLYGFGLGEVRLSLQAAG
CLIQYVKDTQRTALPHINAITRFNQCDSIVLDAATRKNLELTRNLQGGSDNTLASVLDNT
ATPMGSRMLQRWIHEPLRNHNIIRARHDAIDELLDNGYHESLHEQLKALGDIERITARLA
IRSARPRDFARLRQALALLPEIQQQLADCNSPHLKALSSHLGDFPEEHALLSRAIVDNPP
MLIRDGGVIKEGYHNELDEWRKLSQGATDYLAELEAREKAATGASTLKVGYNRVHGYYIE
VSRRESDLVPMSYQRRQTLKNTERYIVAELKEHEEKVLSSQGKALALEKQLWEELFDLLM
PRLHELQAFARAAAELDVITNFAERAEQLDYHRPELTAQSGIHIEAGRHPVVERVSQTPF
IANPVSLNPARRMLIVTGPNMGGKSTYMRQVALITLMAHIGSFVPAQKAAIGPVDRIFTR
IGAADDLASGRSTFMVEMTETANILHNATPESLVLMDEIGRGTSTYDGLSLAWSAAEHLA
QNLKSMTLFATHYFELTQLPDQMENVANVHLDAIEHDDTIAFMHAVQEGAASKSYGLQVA
ALAGVPAKVVQAAKHKLHHLESRDREEELPELRQAQLSMTMPETSKALDRLDTIDPDSLT
PRQALDLLYELKQLR