Protein Info for Shew_1101 in Shewanella loihica PV-4
Annotation: peptidylprolyl isomerase, FKBP-type (RefSeq)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 47% identical to FKBX_ECOL6: FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase (fkpB) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
KEGG orthology group: K03774, FKBP-type peptidyl-prolyl cis-trans isomerase SlpA [EC: 5.2.1.8] (inferred from 100% identity to slo:Shew_1101)MetaCyc: 47% identical to peptidyl-prolyl cis-trans isomerase FkpB (Escherichia coli K-12 substr. MG1655)
Peptidylprolyl isomerase. [EC: 5.2.1.8]
Predicted SEED Role
"FKBP-type peptidyl-prolyl cis-trans isomerase SlpA (EC 5.2.1.8)" (EC 5.2.1.8)
Isozymes
Compare fitness of predicted isozymes for: 5.2.1.8
Use Curated BLAST to search for 5.2.1.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A3QBX4 at UniProt or InterPro
Protein Sequence (140 amino acids)
>Shew_1101 peptidylprolyl isomerase, FKBP-type (RefSeq) (Shewanella loihica PV-4) MTVTRSLLCHMNILLEDGSTADSTKASGKPAKLNIGDQSLSPAFEAELSNLKQGDKHSFT LAAADAFGESNPDAIHHMDRSKFPADMQLETGVIVSFAGPGGSEIPGIVREVVGDSVTVD LNHPLAGRAVTFELEVVQEL