Protein Info for Shew_1055 in Shewanella loihica PV-4

Name: era
Annotation: GTP-binding protein Era (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00231: small GTP-binding protein domain
  • amino acids 36 to 199 (164 residues), 122.4 bits, E=1.6e-39
• TIGR00436: GTP-binding protein Era
  • amino acids 38 to 311 (274 residues), 341.3 bits, E=4e-106
• PF10662: PduV-EutP
  • amino acids 40 to 198 (159 residues), 21.4 bits, E=7.6e-08
• PF00009: GTP_EFTU
  • amino acids 40 to 205 (166 residues), 27.8 bits, E=7.4e-10
• PF01926: MMR_HSR1
  • amino acids 40 to 156 (117 residues), 94.1 bits, E=2.5e-30
• PF02421: FeoB_N
  • amino acids 40 to 198 (159 residues), 50 bits, E=1e-16
• PF04548: AIG1
  • amino acids 41 to 143 (103 residues), 29.2 bits, E=2.2e-10
• PF07650: KH_2
  • amino acids 240 to 316 (77 residues), 69.1 bits, E=9.4e-23

Best Hits

Swiss-Prot: 69% identical to ERA_YERE8: GTPase Era (era) from Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

KEGG orthology group: K03595, GTP-binding protein Era (inferred from 100% identity to slo:Shew_1055)

MetaCyc: 68% identical to 30S ribosomal subunit maturation GTPase Era (Escherichia coli K-12 substr. MG1655)
3.6.1.15,3.6.5.6,3.6.5.5,3.6.5.4,3.6.5.3,3.6.5.2,3.6.5.1,3.6.1.-,3.6.1.5 [EC: 3.6.1.15, 3.6.1.5, 3.6.5.1, 3.6.5.2, 3.6.5.3, 3.6.5.4, 3.6.5.5, 3.6.5.6]

Predicted SEED Role

"GTP-binding protein Era" in subsystem Bacterial Cell Division or Universal GTPases

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (14/14 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (9/9 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (8/9 steps found)
• pyrimidine deoxyribonucleotides biosynthesis from CTP (7/8 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis IV (6/7 steps found)
• UTP and CTP dephosphorylation I (5/7 steps found)
• UTP and CTP dephosphorylation II (1/3 steps found)

KEGG Metabolic Maps

• Purine metabolism
• Pyrimidine metabolism
• Thiamine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.15

Use Curated BLAST to search for 3.6.1.15 or 3.6.1.5 or 3.6.5.1 or 3.6.5.2 or 3.6.5.3 or 3.6.5.4 or 3.6.5.5 or 3.6.5.6

Sequence Analysis Tools

See A3QBS8 at UniProt or InterPro

Protein Sequence (331 amino acids)

>Shew_1055 GTP-binding protein Era (RefSeq) (Shewanella loihica PV-4)
MSNKPEQPEGAQEPSLDELLARMNSGRSGSQYEVTYCGMVAIVGRPNVGKSTLLNKLLGQ
KISITSKKPQTTRHRIMGIHTDGPRQVVFIDTPGLHIEEKRAINRLMNRAASSSLAEVSL
VVFVVDGLNWTADDEMVLKKLHNRDDGRKTILAINKVDNIKDKEALFPHLQTLAAKFEFD
EILPISATHGTNVQRIMELALESVPESPHYFPEDYVTDRSQKFMASEIVREKLMRFLGDE
LPYDATVEIEQFKMMENGVYQINALILVERETQKRMVIGNKGERIRTIATQARQDMEVLF
DNKVFLEVWVKVKSGWADDERALRSLGYGES