Protein Info for Shew_1050 in Shewanella loihica PV-4

Annotation: sigma E regulatory protein, MucB/RseB (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 310 signal peptide" amino acids 1 to 18 (18 residues), see Phobius details PF03888: MucB_RseB" amino acids 22 to 196 (175 residues), 183.9 bits, see alignment E=2.1e-58 PF17188: MucB_RseB_C" amino acids 212 to 307 (96 residues), 95.3 bits, see alignment E=2.1e-31

Best Hits

KEGG orthology group: K03598, sigma-E factor negative regulatory protein RseB (inferred from 100% identity to slo:Shew_1050)

Predicted SEED Role

"Sigma factor RpoE negative regulatory protein RseB precursor" in subsystem Transcription initiation, bacterial sigma factors

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QBS3 at UniProt or InterPro

Protein Sequence (310 amino acids)

>Shew_1050 sigma E regulatory protein, MucB/RseB (RefSeq) (Shewanella loihica PV-4)
MRLIWLALLVLVFPASAQEELSAKAWLENMSLALKGQEFKMSLIHLQADHIRPLVYLHGK
VDDHEVAFLEHLNGPPKNAVRVGNTVTFIEHDQPAYSVRAERIQGVLPPAFAGVISDLES
GYQFVLGGRSRLAGRPSQLVRIIPNDDNRYSYQVWLDMDTYLPLRYDMLNLEKQLLEQVL
VVELIVLDDAPAILREAYKQDWPEIMPQPQREQADNWQFKWLPQGFKILVKDNHRLIGSH
EAVEYIALSDGLVNISVYVARAGETALPDELMTRNGLSLAAERVGNAEVVAVGKVPAETL
SRIAKSITIE