Protein Info for Shew_0907 in Shewanella loihica PV-4

Annotation: PAS/PAC sensor hybrid histidine kinase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 919 PF08447: PAS_3" amino acids 275 to 360 (86 residues), 52.1 bits, see alignment E=1.3e-17 PF00512: HisKA" amino acids 405 to 470 (66 residues), 61.2 bits, see alignment 1.6e-20 PF02518: HATPase_c" amino acids 517 to 636 (120 residues), 99.6 bits, see alignment E=3.1e-32 PF00072: Response_reg" amino acids 797 to 911 (115 residues), 83.3 bits, see alignment E=2.9e-27

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_0907)

Predicted SEED Role

"Signal transduction histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QBD0 at UniProt or InterPro

Protein Sequence (919 amino acids)

>Shew_0907 PAS/PAC sensor hybrid histidine kinase (RefSeq) (Shewanella loihica PV-4)
MAPAGNSIDDSPFAQLICDKQGVIIEANDALYALFELNHEAVVKRPLEQLLTLNQTDSSD
SLLEAITHALALTLADRQSLDVRLHRQSRTPWYQLFPQALSNNRYLLLFVPQRDDPNINQ
AYLKRFEAFLCSADIGIWHYDSTTGETRFSNRVKELLQLNHHSPLSWQSLQQMVTVKDRY
KFDPFLAPSPSGKHKLAFRFRIDSNDVARVYELFAEHIYLENGHFKLLGLIKDQTESKAM
LDALNEANESKKLALEAGNIGNWRAQIDEQGQWIWQWDQRANEMFCLNIEDIGVLEKWAE
RIHPEDFPAVMAAVEDSLANGNPFHQEYRAILPNQEIIYILAKGKVSQGQNQQNSRIDGI
CIDQTPIYQARLALQESYRSLESRVKQRTTELQLAKERAEIASQAKSEFLSMISHELRTP
MNAVIGALELLSLADKSGEERDLIETASTSANNLIYILNDILDINKIESGKMQLEQQDFH
LAGVIADLIKSFSPVASRQGLRFAVQEALELPDWVEGDIVKVRQILSNLLSNAMKFTHST
QEQTGCVSLNITVGEQNDIVTRVRFTVTDNGIGIDKATQKRLFTPFVQAQRSTTRNYGGT
GLGLAICGKLTNLMGGSISLKSELGQGAQFCVELPFWRAHHHEQTQELSEHTIGMVNLGQ
PQTTLDWIKQCLTDKGGRVKCYQAEQLGIDTLALPLVIILATGEADELRFLANQAASPKG
HSNWLVALPQHQRKALTQTIPQIDSLDSYLLSKALLLKAVHKRLNTGLAIDLDEMELDLC
DPLTQEPMPGLKGDADILVVEDNPLNQKLILKQLDMLGYRCNLAEDGLAGVHLWQSADYK
LILTDCHMPNLDGYDMSKQIRQIENSTQRKSVPIVAITGAAMATELDDCYRSGMNDFVSK
PVQLRDLKKVIQKWYRHEE