Protein Info for Shew_0736 in Shewanella loihica PV-4

Annotation: aldo/keto reductase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 346 PF00248: Aldo_ket_red" amino acids 15 to 338 (324 residues), 238.9 bits, see alignment E=3.4e-75

Best Hits

Swiss-Prot: 56% identical to TAS_ECOLI: Protein tas (tas) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 100% identity to slo:Shew_0736)

Predicted SEED Role

"Oxidoreductase Tas, aldo/keto reductase family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QAW0 at UniProt or InterPro

Protein Sequence (346 amino acids)

>Shew_0736 aldo/keto reductase (RefSeq) (Shewanella loihica PV-4)
MDYTRLPHSSLDVSKICLGTMTWGEQNTQAQAFEQLDYAIGQGINFIDTAEMYPVPPKAE
TQGETERILGNYLKARGKRDDLIIATKVAAPGGKSDYIRQNMALDWRNIHQAVNDSLERL
QIETIDLYQLHWPDRNTNFFGELFYEQQDDEKLTPIIDTLEALADLIKAGKIRYIGVSNE
TPWGLMKYLQLAEKHGLPRIISVQNPYNLLNRSFEVGMAEIAHREELPLLAYSPLAFGAL
SGKYIGGQWPEGARLTLFKRFARYTGSQMALDATQAYVELAREFNLSPAQMALAFVNGRR
FVGSNIIGATNLEQLKENIDSTSVSLSAELMGRIDELAAIYRIPCP