Protein Info for Shew_0729 in Shewanella loihica PV-4

Annotation: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 566 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF07992: Pyr_redox_2" amino acids 3 to 305 (303 residues), 196.1 bits, see alignment E=1.8e-61 PF00070: Pyr_redox" amino acids 153 to 223 (71 residues), 52.2 bits, see alignment E=1.5e-17 PF02852: Pyr_redox_dim" amino acids 349 to 450 (102 residues), 52.8 bits, see alignment E=8.4e-18 PF00581: Rhodanese" amino acids 482 to 561 (80 residues), 46.8 bits, see alignment E=7.1e-16

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_0729)

Predicted SEED Role

"CoA-disulfide reductase (EC 1.8.1.14)" (EC 1.8.1.14)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.1.14

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QAV3 at UniProt or InterPro

Protein Sequence (566 amino acids)

>Shew_0729 FAD-dependent pyridine nucleotide-disulphide oxidoreductase (RefSeq) (Shewanella loihica PV-4)
MKKILIIGGVAGGASAAARARRLSETAEIIMFERGEYVSFANCGLPYHISGEIAQRSALV
LQTPESFKARFNVEVRVKHEVVAIDRAAKLVTVRRLLDGSEYQESYDTLLLSPGAAPIVP
PIPGVDNPLTHSLRNIPDMDRILQTIQMNNVEHATVVGGGFIGLEMMESLHHLGIKTTLL
ELADQVMTPVDREMAGFAHQAIRDQGVDLRLGTALSEVSYQVQTHVASDAAGEDTAHQHI
KGHLSLTLSNGELLETDLLIMAIGVRPETQLARDAGLAIGELGGIKVNAMMQTSDPAIYA
VGDAVEEQDFVTGQACLVPLAGPANRQGRMAADNMFGREERYQGTQGTAICKVFDLAVGA
TGKNEKQLKQAGIAFEKVYVHTASHASYYPGAEVVSFKLLFDPVKGTIFGAQAVGKDGID
KRIDVMAVAQRAGMTVEQLQHLELSYAPPYGSAKDVINQAAFVASNIIKGDATPIHFDQI
DNLSEDQLLLDVRNPGELQNGGLEGAVNIPVDELRDRMHELPKDKEIIIFCQVGLRGNVA
YRQLVNNGYRARNLIGGYRTYKFASV