Protein Info for Shew_0645 in Shewanella loihica PV-4

Annotation: type II and III secretion system protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 436 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF13629: T2SS-T3SS_pil_N" amino acids 26 to 87 (62 residues), 56.5 bits, see alignment E=1.8e-19 PF00263: Secretin" amino acids 250 to 405 (156 residues), 140.8 bits, see alignment E=3.4e-45

Best Hits

KEGG orthology group: K02280, pilus assembly protein CpaC (inferred from 100% identity to slo:Shew_0645)

Predicted SEED Role

"General secretion pathway protein D"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QAL9 at UniProt or InterPro

Protein Sequence (436 amino acids)

>Shew_0645 type II and III secretion system protein (RefSeq) (Shewanella loihica PV-4)
MKTLKIIAFFWICLLLPASSMAHNNRPMKLYVGAVELYKAANVERIVVGNGKVLSAKVVD
NKGVLLIGEAPGNTDLQLWQKDGKLIKLSLTVTPDNSLRTTTMVKKMLAAFPSLTVSESD
GLIIVQGEADLAQKEQLEKILEGDPNVVSLVKYLKFAKTMSPMVKMQVKIVEFNKSTLNN
VGIKWETSMAGPAYGVAKGFTANPIFNVASPGQYTEAITKSITENIGVLDTRGWSSLGIV
SGIGSQIQLLSEKGDARLLAQPNLTTRSGESASFLAGGEFPIRSVSGLGAVDVEYKEYGI
KLDIEPVVDEQQNIVSRVMAEVSSIDPSVAVDGVPGMLTRRTESVINVKNNETIVISGLV
NSEMSKIVNKFPLLGDIPILGELFKSRDFKDDKTELVIFVTPVVVYPGQEEHDTQLNRGL
EMAEEATKLEAFYILD