Protein Info for Shew_0580 in Shewanella loihica PV-4

Annotation: succinylglutamic semialdehyde dehydrogenase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 487 TIGR03240: succinylglutamate-semialdehyde dehydrogenase" amino acids 4 to 486 (483 residues), 812.5 bits, see alignment E=6.1e-249 PF00171: Aldedh" amino acids 10 to 461 (452 residues), 399.5 bits, see alignment E=8.6e-124

Best Hits

Swiss-Prot: 91% identical to ASTD_SHEPW: N-succinylglutamate 5-semialdehyde dehydrogenase (astD) from Shewanella piezotolerans (strain WP3 / JCM 13877)

KEGG orthology group: K06447, succinylglutamic semialdehyde dehydrogenase [EC: 1.2.1.71] (inferred from 100% identity to slo:Shew_0580)

MetaCyc: 58% identical to aldehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Succinylglutamate-semialdehyde dehydrogenase. [EC: 1.2.1.71]

Predicted SEED Role

"Succinylglutamic semialdehyde dehydrogenase (EC 1.2.1.71)" in subsystem Arginine and Ornithine Degradation (EC 1.2.1.71)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.71

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QAF4 at UniProt or InterPro

Protein Sequence (487 amino acids)

>Shew_0580 succinylglutamic semialdehyde dehydrogenase (RefSeq) (Shewanella loihica PV-4)
MMSQFINGQWVAGLGHDVVSKNPANQEVIWESKTATPEQVNAAVEAARAAQFDWFMLGFD
ARLAIVEAYRDQLEAHKGDIAEVIAQETGKPQWETATEAGAMIGKIGLSVAAYHKRTGTS
ENDTPAGRAVLRHKPHGVVAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSELTPKTAEL
MLKLWEKAGLPAGVINLVQGEVETGKALASHPQIDGLFFTGSSRTGHILHQQYAGHPGKI
LALEMGGNNPLIIKGVKDTLAAVHDIIQSAYISSGQRCTCARRLYVEKGAEGDALLAKLA
EAVKQIKVGPWNAQPQPFMGSMISEAAAKGMVEAQRNLINLGGTPLVELKHLEAGTGLVS
PGLIDVTQVIELPDEEYFGPLLQVVRYTDFDEAIKLANDTRYGLSAGILADSREDYDYFL
ARIRAGIVNWNKQITGASGSAPFGGVGASGNHRASAFYAADYCAYPVASVEADALAMPAS
LSPGLTL