Protein Info for Shew_0564 in Shewanella loihica PV-4

Annotation: DNA mismatch repair protein MutL (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 631 TIGR00585: DNA mismatch repair protein MutL" amino acids 1 to 309 (309 residues), 324.4 bits, see alignment E=5.1e-101 PF02518: HATPase_c" amino acids 21 to 77 (57 residues), 33.3 bits, see alignment 1.1e-11 PF13589: HATPase_c_3" amino acids 24 to 120 (97 residues), 57.4 bits, see alignment E=3.3e-19 PF01119: DNA_mis_repair" amino acids 213 to 328 (116 residues), 121.5 bits, see alignment E=3.1e-39 PF08676: MutL_C" amino acids 463 to 573 (111 residues), 52.7 bits, see alignment E=7.9e-18

Best Hits

Swiss-Prot: 100% identical to MUTL_SHELP: DNA mismatch repair protein MutL (mutL) from Shewanella loihica (strain ATCC BAA-1088 / PV-4)

KEGG orthology group: K03572, DNA mismatch repair protein MutL (inferred from 100% identity to slo:Shew_0564)

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QAD8 at UniProt or InterPro

Protein Sequence (631 amino acids)

>Shew_0564 DNA mismatch repair protein MutL (RefSeq) (Shewanella loihica PV-4)
MTIRILPPQLANQIAAGEVVERPASVIKELVENSLDAGATRVDIEIDKGGSKLIKITDNG
SGIPKEELSLALSRHATSKLASLDDLDAILSFGFRGEALASISSVSRLTLTSRTQEQSEA
WQAYAEGSEMAVRVIPAAHPVGSTVEAADLFFNTPARRRFLKSDKTEFTHIDEWLKRIAL
VRSEIHFTLKHNGKQVRNYRPAKTEAQYLQRLAQVSGKAFADNALRVDCNHNGLSLSGYI
QSPFSEMAVGDTQYFYVNGRLVRDRLVNHAVRQAFAQQLQGEQVAFVLMLNLDPHQVDVN
VHPAKHEVRFHESRYVHDFILQALESALRQSSELAFEAALDTQVTDQNRSASYIRPLQTQ
QSDTGSNQIAHGDTEENALWLANERPAYGEREASRQAGGQRVQETQMSSYGSGQSGGRGR
SYASTELPSQAAVDSYAQLMTTPGVSSQANQADDSHLPPMPQVLDGQYWLLVRGSELALL
SLSCAAREVTRREIEAKLDAGLIGQPLLMPVSVKVDEDWQQTLVERELLVRKLGLELTIR
LGQLIIKKVPPYLRQSQLASVIPEFLQWIRFEEPTTEALVNWLVNQSGEQFNSASRLWAG
LMGLPESQQQEILSLAKVMPWQTWLGEQTSE