Protein Info for Shew_0533 in Shewanella loihica PV-4

Annotation: excinuclease ABC, A subunit (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 941 TIGR00630: excinuclease ABC subunit A" amino acids 3 to 924 (922 residues), 1490.1 bits, see alignment E=0 PF17760: UvrA_inter" amino acids 130 to 237 (108 residues), 127.4 bits, see alignment E=5.4e-41 PF17755: UvrA_DNA-bind" amino acids 289 to 398 (110 residues), 126.3 bits, see alignment E=1.7e-40

Best Hits

Swiss-Prot: 81% identical to UVRA_ECOLI: UvrABC system protein A (uvrA) from Escherichia coli (strain K12)

KEGG orthology group: K03701, excinuclease ABC subunit A (inferred from 79% identity to aap:NT05HA_2208)

MetaCyc: 81% identical to UvrABC excision nuclease subunit A (Escherichia coli K-12 substr. MG1655)
3.1.25.-

Predicted SEED Role

"Excinuclease ABC subunit A" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QAA7 at UniProt or InterPro

Protein Sequence (941 amino acids)

>Shew_0533 excinuclease ABC, A subunit (RefSeq) (Shewanella loihica PV-4)
MDKIEVRGARTHNLKNINLTIPRDKLIVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAY
ARQFLSLMEKPDVDHIEGLSPAISIEQKSTSHNPRSTVGTITEIYDYLRLLFARVGEPRC
PTHNQPLAAQTVSQMVDKVLTLPEGSRQMLLAPVINDRKGEHVKLLDSLAAQGFIRARID
GEVCDLSDPPALELHVKHTIEVVVDRFKVRDDLQQRLAESFETALELSGGIATVASMDGD
SEELLFSANFACTHCGYSMAELEPRIFSFNNPAGACPTCDGLGVQQFFDADRVITNTELS
LAGGAIRGWDRRNFYYFQMLTSLAEHYKFDVEAPFEKLSAKIRNIVLHGSGKESIAFKYI
NDRGDVVVRNHPFEGILNNMDRRYRETESNAVREELAKYINTQACSSCGGSRLREEARHV
FIEDLNLPRLTDWSIGEAMEYFEQLSLTGQRAQIAEKILKEVRDRLGFLVNVGLNYLSLS
RSADTLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLNTLIHLRDLGNTV
IVVEHDEDAIRMADHIIDIGPGAGVHGGQVICDGPLKEIVACDESVTGQYISGKKQIHIS
EKRAQYDASKVIELFGASGNNLKQVDLTIPVGLFTCVTGVSGSGKSTLINDTFYKIAHRQ
LNGATVDEPAPYKKVAGMDHCDKVVDIDQSPIGRTPRSNPATYTGIFTPIRELFAATQEA
RTRGYKPGRFSFNVKGGRCEACQGDGLIKVEMHFLPDVYVPCDSCKSKRYNRETLEVRYK
GKNIHEVLEMTVEEAREFFDAVPAIARKLQTLMEVGLSYIGLGQSATTLSGGEAQRVKLA
KELSKRDTGKTLYILDEPTTGLHFADIQLLLDVLHRLKAHGNTIVVIEHNLDVIKTADWI
VDLGPEGGSGGGTILVSGTPEQVAEHPSSHTARFLKPLLKG